Warfarin-induced leukocytoclastic vasculitis and proteinuria

Abstract

Warfarin is typically prescribed for patients with thromboembolic diseases and atrial fibrillation. In addition to the complications of bleeding, allergic skin reaction is one of its rare adverse effects. We herein report a case of a 79 year old male patient with leukocytoclastic vasculitis and proteinuria secondary to warfarin. The warfarin was discontinued and oral prednisone therapy was initiated. The cutaneous lesions and the proteinuria resolved thereafter.

Colloidal Silver Ingestion Associated with Leukocytoclastic Vasculitis in an Adolescent Female

“…Literature highlights drugs that induce leukocytoclastic vasculitis include antibiotics, especially beta-lactams, tumor necrosis factor (TNF) inhibitors, propylthiouracil, levamisole-adulterated cocaine, warfarin, hydralazine, minocycline, indomethacin, and most recently trimethoprim- sulfamethoxazole [5,7,8]. Some rare cases of leukocytoclastic vasculitis induced by anti-tuber-culoid therapy have been reported in the pediatric population with ethambutol and rifampicin therapy in Japan [11], and with rifampicin and pyrazinamide therapy in India [12].…”

“…Well-documented diseases that are associated with leukocytoclastic vasculitis include autoimmune conditions, connective tissue disease, neoplasia, and a wide array of infections including, hepatitis C, beta-hemolytic streptococcus A, myco-bacterium, chlamydia, Neisseria infection, tuberculosis, and HIV/AIDS [2,4]. Certain drug ingestions have been associated with the development of leukocytoclastic vasculitis including warfarin, naproxen, and trimethoprim–sulfamethoxazole [5–7].…”