Warfarin Interaction With Erythromycin

Sato, Ronald I.

doi:10.1001/archinte.1984.00350220145031

Cited by 34 publications

(6 citation statements)

References 6 publications

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“…The CIG for the respiratory tract infection suggests, among the others, the treatment with Erythromycin (an antibiotic). The drug interaction between Erythromycin and Warfarin is well known in medical literature (see, e.g., [10]) and, in our model, it is represented by an interaction between the anticoagulant effect of Warfarin and the metabolism reduction caused by Erythromycin. Their concomitant use increases the anticoagulant effect of Warfarin, raising the risk of bleedings.…”

Section: Example 1 (Description and Non-temporal Analysis)mentioning

confidence: 99%

Temporal reasoning techniques for the analysis of interactions in the treatment of comorbid patients

Anselma

Piovesan

Terenziani

2017

Proceedings of the Symposium on Applied Computing

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Section: Example 1 (Description and Non-temporal Analysis)mentioning

confidence: 99%

Temporal reasoning techniques for the analysis of interactions in the treatment of comorbid patients

Anselma

Piovesan

Terenziani

2017

Proceedings of the Symposium on Applied Computing

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“…14 Bachmann carried out a study of 12 normal subjects and showed that the clearance of a single dose of warfarin was reduced by an average of 14% after taking erythromycin 250 mg orally qds for 8 days. 15 Other studies have shown an increase in warfarin activity with erythromycin, [16][17][18][19][20][21][22][23] however, two studies showed only a small increase. 24,25 …”

Section: Clinical Evidencementioning

confidence: 99%

Antibacterial prescribing and warfarin: a review

et al. 2003

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Warfarin is the most commonly prescribed oral anticoagulant and is used in the management of thromboembolic disease. The practitioner is regularly faced with the need to prescribe concurrent antimicrobial therapy, either as prophylactic cover or in the therapeutic management of existing infection. Much has been written about the possible influence of antibiotics on the prothrombin time of patients taking warfarin, particularly in the form of isolated case reports, however evidence, in the form of controlled studies, is not always forthcoming. This review attempts to summarise current knowledge and, with reference to basic science, suggest possible management strategies when faced with a prescribing dilemma.

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“…Numerous case reports describing an erythromycin/warfarin interaction have been published, [161][162][163][164][165][166] with a marked increase in prothrombin time and haemorrhage occurring in several cases. warfarin) are widely used vitamin K antagonists suited for both long and short term anticoagulation.…”

Section: Oral Anticoagulantsmentioning

confidence: 99%

Macrolide Antibacterials

Rosensteil¹,

Adam²

1995

Drug Safety

145

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Macrolide antibiotics can interact adversely with commonly used drugs, usually by altering metabolism due to complex formation and inhibition of cytochrome P-450 IIIA4 (CYP3A4) in the liver and enterocytes. In addition, pharmacokinetic drug interactions with macrolides can result from their antibiotic effect on microorganisms of the enteric flora, and through enhanced gastric emptying due to a motilin-like effect. Macrolides may be classified into 3 different groups according to their affinity for CYP3A4, and thus their propensity to cause pharmacokinetic drug interactions. Troleandomycin, erythromycin and its prodrugs decrease drug metabolism and may produce drug interactions (group 1). Others, including clarithromycin, flurithromycin, midecamycin, midecamycin acetate (miocamycin; ponsinomycin), josamycin and roxithromycin (group 2) rarely cause interactions. Azithromycin, dirithromycin, rikamycin and spiramycin (group 3) do not inactivate CYP3A4 and do not engender these adverse effects. Drug interactions with carbamazepine, cyclosporin, terfenadine, astemizole and theophylline represent the most frequently encountered interactions with macrolide antibiotics. If the combination of a macrolide and one of these compounds cannot be avoided, serum concentrations of concurrently administered drugs should be monitored and patients observed for signs of toxicity. Rare interactions and those of dubious clinical importance are those with alfentanil and sufentanil, antacids and cimetidine, oral anticoagulants, bromocriptine, clozapine, oral contraceptive steroids, digoxin, disopyramide, ergot alkaloids, felodipine, glibenclamide (glyburide), levodopa/carbidopa, lovastatin, methylprednisolone, phenazone (antipyrine), phenytoin, rifabutin and rifampicin (rifampin), triazolam and midazolam, valproic acid (sodium valproate) and zidovudine.

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Warfarin Interaction With Erythromycin

Cited by 34 publications

References 6 publications

Temporal reasoning techniques for the analysis of interactions in the treatment of comorbid patients

Temporal reasoning techniques for the analysis of interactions in the treatment of comorbid patients

Antibacterial prescribing and warfarin: a review

Macrolide Antibacterials

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