Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats

Wada, Masahiro; Kumagai, Kenji; Murata, Masakazu; S-Yamashita, Yasuko; Shindo, Hiroyuki

doi:10.1007/s00776-004-0829-9

Cited by 20 publications

(19 citation statements)

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“…These reactions might be important factor in onset of osteonecrosis of femoral head. Several studies reported that a combination of anticoagulant and lipid-lowering agent showed a significant decrease in the onset of osteonecrosis compared with an anticoagulant or a lipidlowing agent alone in human and animal models (14,15,20). Another report suggested that a high serum PAI-1 level may be a risk factor for the development of osteonecrosis of the femoral head by studying thrombophilis and hypofibrolysis patients (4, 6).…”

Section: Discussionmentioning

confidence: 99%

Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes

et al. 2010

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Several studies have demonstrated the association of plasminogen activator inhibitor-1 (PAI-1) with osteonecrosis, but the underlying mechanism of osteonecrosis and its relationship with local PAI-1 is not clear. The objective of this study was to evaluate PAI-1 production by primary human bone marrow adipocytes and the effects of glucocorticoid administration. Bone marrow was obtained from 25 individuals during prosthetic insertion. Mature adipocytes were cultured for 24 h with or without dexamethasone. PAI-1, adiponectin, tumor necrosing factor-α (TNFα) expression were measured by latex photometric immunoassay or RT-PCR. Adiponectin, TNFα and PAI-1 were detected in all culture media. PAI-1 expression was significantly increased by treatment with 10 −6 mol/L dexamethasone up to 24 h in protein and mRNA levels, while the levels of other adipokines did not change by dexamethasone. These results suggest that bone marrow adipocytes may play important roles for the development of glucocorticoid-induced osteonecrotic diseases by enhancing PAI-1 expression.

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Section: Discussionmentioning

confidence: 99%

Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes

et al. 2010

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“…ON is frequently found in spontaneously hypersensitive rats [41][42][43][44]. Hirano et al [45] suggested that ON in the femoral head of spontaneously hypersensitive male rats was attributed to abnormality of the cartilage in the epiphysis and metaphyseal growth plate and subsequent enchondral ossification.…”

Section: Spontaneous Onfhmentioning

confidence: 99%

Experimental animal models of osteonecrosis

et al. 2011

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Osteonecrosis (ON) or avascular necrosis (AVN) is a common bone metabolic disorder, mostly affecting femoral head. Although many biological, biophysical, and surgical methods have been tested to preserve the femoral head with ON, none has been proven fully satisfactory. It lacks consensus on an optimal approach for treatment. This is due, at least in part, to the lack of ability to systematically compare treatment efficacy using an ideal animal model that mimics full-range osteonecrosis of femoral head (ONFH) in humans with high incidence of joint collapse accompanied by reparative reaction adjacent to the necrotic bone in a reproducible and accessible way. A number of preclinical animal ON models have been established for testing potential efficacy of various modalities developed for prevention and treatment of ON before introduction into clinics for potential applications. This paper describes a number of different methods for creating animal experimental ON models. Advantages and disadvantages of such models are also discussed as reference for future research in battle against this important medical condition.

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“…Un effet protecteur de la survenue d'ONTF a été observé dans le modèle de rat spontanément hypertendu [28]. Une étude randomisée a évalué l'effet de la warfarine, commencée en même temps que la corticothérapie chez 60 patients lupiques [29].…”

Section: Préventionunclassified

Ostéonécrose de la tête fémorale

Lafforgue

2009

Revue du Rhumatisme

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Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats

Cited by 20 publications

References 15 publications

Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes

Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes

Experimental animal models of osteonecrosis

Ostéonécrose de la tête fémorale

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