2023
DOI: 10.1016/j.scitotenv.2022.160163
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Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19

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Cited by 14 publications
(51 citation statements)
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“…For certain aspects the contention also does not appear to hold for SARS-CoV-2; for example, a higher proportion of patients infected with BA.5 develop anosmia, when compared with BA.1 14 . Anosmia was recently closely linked to long-lasting cognitive problems in COVID-19 patients 123 , with infection of the olfactory epithelium potentially proving access to the brain 53,112 . The data herein would support the view that BA.5 has developed an increased propensity for neuroinvasiveness over earlier omicron variants.…”
Section: Discussionmentioning
confidence: 99%
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“…For certain aspects the contention also does not appear to hold for SARS-CoV-2; for example, a higher proportion of patients infected with BA.5 develop anosmia, when compared with BA.1 14 . Anosmia was recently closely linked to long-lasting cognitive problems in COVID-19 patients 123 , with infection of the olfactory epithelium potentially proving access to the brain 53,112 . The data herein would support the view that BA.5 has developed an increased propensity for neuroinvasiveness over earlier omicron variants.…”
Section: Discussionmentioning
confidence: 99%
“…Genotyping was undertaken by PCR and sequencing across a SNP that associates with the hACE2 transgene 129 to distinguish heterozygotes (TTTG(A/C)AAAC) from homozygotes (TTTGCAAAC). The mice were held under standard animal house conditions, and were infected intrapulmonary via the nasal route with 5×10 4 CCID 50 of virus in 50 μL RPMI while under light anesthesia as described 53 . Mice were weighed and overt disease symptoms scored as described 53 .…”
Section: Methodsmentioning
confidence: 99%
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“…Mice were sorted into groups so that each group had a similar mean age and age distribution, and in the case of Irf7 -/- mice, had equal numbers of males and females in each group. All mice strains except C57BL/6J were bred in-house at QIMR Berghofer MRI, and mice housing conditions were described previously (26). Mice were infected subcutaneously (s.c.) at the base of the tail with 100 µl of virus inoculum (doses ranging from 5×10 2 to 5×10 5 as indicated in the figure legends).…”
Section: Methodsmentioning
confidence: 99%