Warthin-like mucoepidermoid carcinoma of the parotid gland: case report

Yan, Limin; Xu, Jianan; Liu, Liyun; Li, Xin

doi:10.21203/rs.3.rs-1637078/v1

Cited by 2 publications

(2 citation statements)

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“…Proliferation of the ductal epithelium and myoepithelium forms characteristic epithelial myoepithelial islands, lacking cellular atypia. The occurrence of these lesions is associated with Sjögren's syndrome (22).…”

Section: Benign Lymphoepithelial Lesionsmentioning

confidence: 99%

Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma

Yang,

Lei,

Lang

et al. 2024

Front. Oncol.

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Warthin-like mucoepidermoid carcinoma (WL-MEC) is a newly reported variant of mucoepidermoid carcinoma. Its histological feature is easy to confused with metaplastic Warthin Tumor, and its relationship with Warthin tumor in histogenesis is controversial. In this study, we presented two cases of WL-MEC, discussing their clinicopathological and molecular features. Notably, one case was initially misdiagnosed during the first onset of the tumor. Case 1 was a 60-year-old female with a mass in the right parotid gland. Case 2 featured a 29-year-old male who developed a lump at the original surgical site 6 months after a “Warthin tumor” resection from the submandibular gland. Histologically, both tumor exhibited a prominent lymphoid stroma and cystic pattern, accompanied by various amounts of epithelial nests composed of squamoid cells, intermediate cells and mucinous cells. The characteristic eosinophilic bilayer epithelium of Warthin tumor was not typically presented in either case. Both cases tested positive for MAML2 gene rearrangement. To contextualize our findings, we conducted a comprehensive review of forty-eight WL-MEC cases documented in the English literature, aiming to synthesizing a reliable differential diagnostic approach. WL-MEC is a rare yet clinically relevant variant, posing a diagnostic pitfall for pathologists. Our study underscores the importance of a meticulous evaluation of both clinical and histological features, coupled with the detection of MAML2 rearrangement, as a credible method for distinguishing WL-MEC from other benign and malignant lesions, particularly metaplastic Warthin tumor.

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Section: Benign Lymphoepithelial Lesionsmentioning

confidence: 99%

Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma

Yang,

Lei,

Lang

et al. 2024

Front. Oncol.

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“…MEC is a highly heterogeneous neoplasm. Multiple variant forms of MEC, including oncocytic [3] , ciliated, sclerosing [4] , Warthin-like [5] , uni-cystic [6] , calcifying [7,8] , and mucoacinar [9] types, have broadened the histologic spectrum of this cancer type. Histological grading is known to in uence MEC prognosis [10] .…”

Section: Introductionmentioning

confidence: 99%

The clinical outcome, pathologic spectrum, and genomic landscape of 454 cases of salivary mucoepidermoid carcinoma

Wang¹,

Yan

et al. 2023

Preprint

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Objectives To investigate the clinicopathological and molecular features of salivary mucoepidermoid carcinoma (MEC).Design The clinical features, treatment outcomes, and pathological parameters of 454 MECs were evaluated, and their genomic features were analyzed using whole-exome sequencing and whole-transcriptome sequencing.Results 414 patients were alive without relapse at follow-up, after an average period of 62 months (1–116 months). The disease progressed after initial treatment in 40 patients. The lungs were the most common site of distant metastasis. For classical MECs, histologic gradings of the AFIP, modified Healey, and MSK systems were significantly associated with recurrence and lymph nodal metastasis; these gradings were significantly related to lymph nodal metastasis for the subtypes. Older age, minor salivary gland involvement, clinical symptoms, high TNM stage, high-grade tumor, and improper surgical modality were the main prognostic factors. BAP1 was the most frequently mutated gene in MEC. Mutations in CDKN2A, MET, and TP53 were more frequently found in aggressive tumor phenotypes. MAML2 rearrangement was observed in 42% of patients, and EWSR1 rearrangement in 8%. Specific genetic events (in TP53 and FBXW7) associated with CRTC1–MAML2 fusion might cause MEC progression and might be associated with unfavorable prognosis.Conclusions A complete understanding of the high heterogeneity of MEC in histology and genetics would help in accurate diagnosis and treatment.

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Warthin-like mucoepidermoid carcinoma of the parotid gland: case report

Cited by 2 publications

References 0 publications

Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma

Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma

The clinical outcome, pathologic spectrum, and genomic landscape of 454 cases of salivary mucoepidermoid carcinoma

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