Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and Paraguay

Soskin, Ana; Vieillefond, Anicke; Carlotti, A.; Plantier, F.; Chaux, Alcides; Ayala, Gustavo; Velázquez, Elsa F.; Cubilla, Antonio L.

doi:10.1016/j.humpath.2011.04.014

Cited by 27 publications

(6 citation statements)

References 33 publications

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“…The noninvasive presentation is typical in countries with low incidence of penile cancer, whereas the invasive presentation is common in countries with high incidence of penile cancer. A geographical comparison revealed that differentiated PeIN was more prevalent in a country (Paraguay) with high incidence of penile cancer and that the contrary occurred with warty or basaloid PeINs, more frequent in a region (France) with low incidence of penile cancer [73]. In our experience, 75% of penile precursor lesions corresponded to differentiated PeIN, and 25% were undifferentiated PeIN.…”

Section: Clinical Featuresmentioning

confidence: 45%

Advances in the pathology of penile carcinomas

Chaux

Cubilla²

2012

Human Pathology

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Section: Clinical Featuresmentioning

confidence: 45%

Advances in the pathology of penile carcinomas

Chaux

Cubilla²

2012

Human Pathology

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“…Differentiated PeIN was found in 68% of our cases, and this predominance may be related to geographical differences in the incidence of invasive lesions. In a previous study we found that differentiated PeIN predominated in a geographical area of high penile cancer incidence (Paraguay), whereas warty and/or basaloid PeINs were more common in a region of low penile cancer incidence (France) [15]. These geographical differences could be explained by clinical or pathological underrecognition of differentiated PeIN or variability in the incidence of HPV-related neoplasms, although more studies are needed to clarify this matter.…”

Section: Discussionmentioning

confidence: 88%

Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients

et al. 2012

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“…In a comparison of two pathological series from Paris (where the incidence of penile cancer is low) and from Paraguay (where the incidence of penile cancer is high), we found that HPV-related PeIN was more prevalent in France and that non-HPV-related differentiated PeIN was more p revalent in Paraguay. 10 In summary, the prospective study by Sudenga et al 1 has provided the first hard data on the conversion of HPV infection in men into specific pathological lesions -common condylomata and PeIN. HPV genotype information might be useful for vaccine preparation.…”

Section: News and Viewsmentioning

confidence: 97%

The natural history of HPV infection in men

Fernández‐Nestosa

Cubilla

2015

Nat Rev Urol

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In men, human papillomavirus (HPV) infection can cause two different types of external genital lesions: condylomata (genital warts) and penile intraepithelial neoplasia (PeIN). A new study provides clinical and molecular data on the progression of HPV infection to condylomata and PeIN, as well as virus genotype information that might be useful for vaccine preparation.A new study by Sudenga et al. 1 was a prospectively designed 24-month follow-up study of a cohort of 3,033 healthy adult men aged 18-70 years, 1,788 of whom had genital human papillomavirus (HPV) detected by PCR and DNA genotyping. The purpose of the study was to describe the progression of HPV to histopathologically diagnosed condylomata (genital warts) and precancerous lesions of the penis (penile intraepithelial neoplasia [PeIN]). The findings of this study are important as little is known about rates of conversion of HPV infection into specific genital lesions in men.The study population came from three countries-the USA, Mexico and Brazil -which have low, medium and high incidences of penile cancer, respectively. However, owing to the existence of substantial regional variations in incidences of penile cancer within the USA and Brazil, the findings might not represent these countries as a whole. 2 External genital lesions were categorized as being condyloma, suggestive of condyloma, PeIN, or not related to HPV; PeIN lesions were subclassified as grade I (low-grade squamous intraepithelial lesion [SIL], II (high-grade SIL), II/III (high-grade SIL) or III (high-grade SIL). The nomenclature and classification of precancerous penile lesions have been historically quite variable, with different terms for the same lesion, including Bowen's disease, erythroplasia of Queyrat, squamous intraepithelial lesion of low and high grades and PeIN. 3 In our experience, penile precancerous and invasive lesions are histologically similar to vulvar precancerous and invasive lesions but not to uterine cervical neoplastic lesions. For these reasons, a different approach to that used for the classification of cervical neoplasia is being considered for invasive penile cancers, separating them into HPV-related and non-HPV-related neoplasms. 4 A new classification model, categorizing PeIN into various subtypes, on the basis of findings from previous studies, 5,6 is also proposed. This model is being adopted by the WHO in a forthcoming edition of the WHO classification of tumours of the urinary system and male genital organs and was endorsed by the International Society of Urological Pathology in Boston in March 2015.In the study by Sudenga et al., 1 HPV infection was found to be very common, occurring in 59% of the patients evaluated. Progression or conversion to condylomata occurred in 86 patients and progression to PeIN occurred in nine patients. This study provides the first prospective clinical and molecular data on the progression of HPV to PeIN. As expected, most-but not all-condylomata were associated with low-risk HPV (HPV6 and HPV11), and most-but not all-PeINs ...

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Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and Paraguay

Cited by 27 publications

References 33 publications

Advances in the pathology of penile carcinomas

Advances in the pathology of penile carcinomas

Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients

The natural history of HPV infection in men

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