Wasser- und Elektrolytbewegung am D�nn-und Dickdarm unter dem Einflu� von Laxantien, ein Beitrag zur Kl�rung ihres Wirkungsmechanismus

Förth, W.; Rummel, W.; Baldauf, J.; Andres, H.; Wilbert, Hannelore

doi:10.1007/bf00537819

Cited by 62 publications

(8 citation statements)

References 23 publications

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“…The isolated rat colonic mucosa shows the pattern of absorption qualitatively (and quantitatively) com parable to in vivo conditions (Forth et at, 1966;Parsons and Paterson, 1965). The absorption figures of this study are within the same range when compared with other in vitro studies on rat colonic tissue (Binder and Rawlins, 1973;Parsons and Paterson, 1965).…”

Section: Discussionsupporting

confidence: 67%

Influence of Rhein on Electrolyte and Water Transfer in the Isolated Rat Colonic Mucosa

Wanitschke¹

1980

Pharmacology

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Section: Discussionsupporting

confidence: 67%

Influence of Rhein on Electrolyte and Water Transfer in the Isolated Rat Colonic Mucosa

Wanitschke¹

1980

Pharmacology

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“…Co lonic potassium secretion was slightly, but significantly enhanced as it has been shown with other laxatives [Forth et al, 1966;Schreiner et al, 1980]. It seems likely that anthraquinones possess a similar pattern of action as other contact cathartics, they prob ably lead to the same severe side effects upon chronic administration, and should be pre scribed with the same precautions.…”

Section: Discussionmentioning

confidence: 85%

Prostaglandin-Mediated Action of Sennosides

Beubler

Kollar²

1988

Pharmacology

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The aim of this study was to investigate whether prostaglandins (PG) are involved in the mediation of sennoside-induced colonic fluid and electrolyte secretion. Oral administration of senna pod extract dose-dependently reversed net absorption of water, sodium and chloride to net secretion, increased potassium secretion and stimulated the release of PGE₂ into the colonic lumen. Inhibition of PG biosynthesis by pretreatment of the rats with indometacin significantly inhibited the effects of senna pod extract both on net fluid transport and on PGE₂ release. The inhibitory effect of indometacin on net fluid transport induced by senna pod extract was dose-dependent. It is concluded that sennosides exert their laxative action at least partially via stimulation of colonic fluid and electrolyte secretion, and that this secretion is mediated by stimulation of endogenous PGE₂ formation.

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“…Further, when administered in higher concentrations, they not only inhibit the net absorption of water and sodium, but also produce a net transfer of fluid and sodium into the lumen. This hydragogue effect has also been described for bisacodyl and isatin in rats (Forth et al, 1966), whereas Ewe and Holker (1974) have shown similar effects in the colon of man after oral bisa codyl administration. In table 111 some results of Lemmens (1974) and Lemmens and Borja (1975) are summarised.…”

Section: Conjugationsmentioning

confidence: 80%

“…With respect to the mechanism of laxative action, Forth et al (1963Forth et al ( , 1966) have provided evidence that certain phenolic laxatives exert their effect by prevention of water absorption or stimulation of water secretion resulting in a net water transport towards the lumen of the colon. Similar experiments with several anthracene derivatives have been carried out by Lemmens (1974) and Lemmens and Borja (1975).…”

Section: Conjugationsmentioning

confidence: 99%