The aims were to determine the polyphenolic profile of red wines from Spanish Designation of Origin (DO) Rías Baixas and Ribeira Sacra and to evaluate the feasibility of using polyphenolic profiles and chemometric tools to classify wines for authentication purposes. Trans-resveratrol, oenin, malvin, (+)-catechin, (−)-epicatechin, quercetin and syringic acid were determined in 39 samples. Soft independent modeling of class analogy (SIMCA), linear discriminant analysis (LDA) and support vector machine classification (SVM) were used to classify. For resveratrol, Ribeira Sacra red wines showed higher values than Rías Baixas wines (4.60 and 3.36 mg L −1 , respectively). SVM classification was adequate for 100 % classification of wines by their polyphenolic profile. SIMCA classification was also adequate for wine classification of DO Rías Baixas and Ribeira Sacra wines. As conclusion, polyphenolic profile can be used for classification of DOs. The models can discriminate outside wines. Thus, this approach can be useful for authentication purposes.