Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp.

Zhang, Yongli; Marrs, Carl F.; Simon, Carl P.; Xi, Chuanwu

doi:10.1016/j.scitotenv.2009.02.013

Cited by 303 publications

(172 citation statements)

References 46 publications

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“…Few of them have focused on the antibiotic-resistant bacteria, among them on E. coli and Acinetabacter spp. in the effluents of WWTPs and their receiving water body (Chen and Zhang, 2013;Schwartz et al 2003;Reinthaler et al 2003;Zhang et al 2009;Gao et al 2012). Reinthaler et al (2003) evaluated resistance patterns of E. coli in wastewater treatment plants (WWTPs).…”

Section: Resultsmentioning

confidence: 99%

“…The decrease in susceptibility of bacterial isolates to antibiotics was probably caused by the presence of these compounds in the wastewaters and the long exposition of E. coli strains to them. Zhang et al (2009) detected that resistance among Acinetobacter isolates to 3 antibiotics (amoxicillin, chloramphenicol and rifampin) and multi-drug resistance (more than 3 antibiotics) significantly increased from the raw influent samples to the final effluent samples.…”

Section: Resultsmentioning

confidence: 99%

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Characteristics of airborne bacteria and fungi in some Polish wastewater treatment plants

Kowalski

Wolany

Pastuszka

et al. 2017

Int. J. Environ. Sci. Technol.

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The aim of this study was to characterize both the viable airborne bacteria and fungi collected in different types of wastewater treatment plants in Poland. Bacterial and fungal aerosols in five different wastewater treatment plants in Poland were studied, including the pioneering antibiotic resistance testing of airborne bacteria. Concentration level was measured using the six-stage Andersen impactor. After incubation, bioaerosol particles captured on nutrient media on Petri dishes were quantitatively evaluated and qualitatively identified. It was found that the concentration levels of both airborne bacteria and fungi ranged from 10 2 to 10 3 colony-forming units/m 3 , in all stages of the wastewater treatment plants. The patterns of size distributions of airborne bacteria and fungi were very similar, showing dominant peaks typically in the size range between 3.3 and 4.7 lm. The majority fraction of small bacterial and fungal particles (less than 4.7 lm) in the studied areas indicates that the bioaerosol is relatively fresh, and mostly of local origin. The Gram-positive cocci and nonsporing Gram-positive rods were the dominating forms in the studied wastewater treatment plants environment. The existing differences in the concentration levels between sampling sites enabled identification of the main bioaerosol sources. The highest concentration of bacterial aerosol appeared in sections, where activated sludge postprocessing and mechanical purifying are conducted. The most frequently occurring species in the sampled bacterial aerosol were Gram-positive cocci and nonsporing Grampositive rods. Multi-antibiotic resistance testing showed that among the isolated airborne bacteria, the most antibiotic-resistant features were present among Bacillus species (especially Bacillus mycoides).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Characteristics of airborne bacteria and fungi in some Polish wastewater treatment plants

Kowalski

Wolany

Pastuszka

et al. 2017

Int. J. Environ. Sci. Technol.

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“…This study and other studies mentioned earlier have shown that antibiotic resistant bacteria can reach surface waters via WWTPs. The biological treatment process in conventional WWTPs may result in a selective increase in the antibiotic resistant bacteria population and the increased occurrence of multidrug resistant bacteria (Zhang et al, 2009). Although the mechanisms that contribute to a selective increase in antibiotic resistant bacteria in WWTPs remain undefined, a number of studies have shown that the conditions in WWTPs favour antibiotic resistant bacteria (Iwane et al, 2001;Schwartz et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Screening municipal wastewater effluent and surface water used for drinking water production for the presence of ampicillin and vancomycin resistant enterococci

Taučer-Kapteijn

Hoogenboezem

Heiliegers

et al. 2016

International Journal of Hygiene and Environmental Health

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The emergence of clinical enterococcal isolates that are resistant to both ampicillin and vancomycin is a cause of great concern, as therapeutic alternatives for the treatment of infections caused by such organisms are becoming limited. Aquatic environments could play a role in the dissemination of antibiotic resistant enterococci. This study investigated the presence of ampicillin and vancomycin resistant enterococci in the treated effluent of six wastewater treatment plants (WWTPs) and in surface water used as a source for drinking water production in the Netherlands. Membrane filtration in combination with selective media with ampicillin or vancomycin was applied to determine the presence of ampicillin resistant Enterococcus (ARE) and vancomycin resistant Enterococcus (VRE) species. Ampicillin resistant E. faecium (minimal inhibitory concentration (MIC) >16 µg/ml; n=1033) was observed in all studied WWTP effluents. In surface water used for drinking water production (intake locations), no ARE or VRE were observed. At both types of location, intrinsic vancomycin resistant Pediococcus spp., Leuconostoc spp. and Lactobacillus spp. were isolated with the vancomycin medium. The ampicillin resistant E. faecium (AREfm) isolates (n=113) did not contain the vanA or vanB gene, but MIC testing for vancomycin showed intermediate vancomycin resistance (2 to 8 µg ml -1 ) to occur in these AREfm strains. This study documents the discharge of ampicillin resistant E. faecium strains with intermediate vancomycin resistance by the WWTPs into the surface water, but no presence of these strains downstream at intake locations for drinking water production.

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“…Recently, this has been demonstrated by the observed increase in antibacterial resistance in Acinetobacter spp. isolates discharged to the environment after conventional activated sludge (CAS) WW treatment (Zhang et al 2009) and the detection of antibiotic resistance genes in surface water to which highly treated municipal WW is discharged (LaPara et al 2011). The estimated antibiotic consumption worldwide ranges from 100,000 to 200,000 t annually (Wise 2002), and due to excretion (which can reach up to 90 % of the ingested amount both as the original parent compound or as metabolites) (Daughton and Ternes 1999;Kümmerer 2009c) and disposal, up to microgram-per-liter levels have been detected in untreated WW (Hirsch et al 1999;Kümmerer 2009a, c, b;Perez et al 2005).…”

Section: Smx Usage and Presence In The Environmentmentioning

confidence: 99%

“…After the β-lactam class of compounds (consisting of penicillin amongst others), sulfonamides are the most commonly used antibiotics in most countries (Kümmerer 2009a) due to their ability to inhibit gram-positive and gramnegative bacteria, as well as protozoa (Zhang et al 2009). The synthetic compound sulfamethoxazole (SMX) is one of the most popularly prescribed and consumed sulfonamide antibiotics (Cavallucci 2007;Hruska and Franek 2012) leading to its presence in the aquatic environment via WW discharge (Avisar et al 2009;Santos et al 2010) and its frequent detection in WWs at up to microgram-per-liter levels and surface waters at nanogram-per-liter levels (Batt et al 2007;Joss et al 2005;Kolpin et al 2002;Miège et al 2009;Peng et al 2006;Yargeau et al 2007;Gao et al 2012a).…”

Section: Smx Usage and Presence In The Environmentmentioning

confidence: 99%

Biodegradation of sulfamethoxazole: current knowledge and perspectives

Larcher

Yargeau

2012

Appl Microbiol Biotechnol

121

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Antibiotic compounds, like sulfamethoxazole (SMX), have become a concern in the aquatic environment due to the potential development of antibacterial resistances. Due to extensive consumption, excretion and disposal, SMX has been frequently detected in wastewaters and surface waters. This has led to numerous studies investigating the nature of SMX, with many researchers focusing on the biodegradation and persistence of SMX during wastewater treatment and in the environment. This review provides a summary of recent developments, outlines the discrepancies in observations and results, and demonstrates the need for further research to determine optimal biological removal strategies for SMX and other antibiotics.

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Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp.

Cited by 303 publications

References 46 publications

Characteristics of airborne bacteria and fungi in some Polish wastewater treatment plants

Characteristics of airborne bacteria and fungi in some Polish wastewater treatment plants

Screening municipal wastewater effluent and surface water used for drinking water production for the presence of ampicillin and vancomycin resistant enterococci

Biodegradation of sulfamethoxazole: current knowledge and perspectives

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