Watch out for neuromyelitis optica spectrum disorder onset or clinical relapse after COVID-19 vaccination: What neurologists need to know?

Paybast, Sepideh; Emami, Ali; Baghalha, Fatemeh; Moghadasi, Abdorreza Naser

doi:10.1016/j.msard.2022.103960

Cited by 7 publications

(13 citation statements)

References 38 publications

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“…Two doses of the COVID-19 vaccine were administered to more than 90% of the subjects, 83.3% of whom were female and had numerous comorbid conditions (77%) prior to treatment. 18 The most common ophthalmic neurophaties linked to the SARS-CoV-2 vaccines were also reported by Elnahry and colleagues. They discovered that all COVID-19 vaccines can cause ophthalmic manifestations like anterior ischemic optic neuropathy (AION), optic neuritis (ON), autoimmune optic neuropathy, and leber hereditary optic neuropathy (LHON).…”

mentioning

confidence: 65%

Optic neuritis associated with COVID-19-related vaccines

Keikha¹,

Zandhaghighi²,

Zahedani³

2023

Vacunas (English Edition)

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mentioning

confidence: 65%

Optic neuritis associated with COVID-19-related vaccines

Keikha¹,

Zandhaghighi²,

Zahedani³

2023

Vacunas (English Edition)

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“…These disorders can cause TM [ 44 ]. NMOSD was reported after mRNA vaccines (86.56%), inactivated vaccines (11.94%), and viral vector vaccines (1.49%) [ 45 ]. MOGAD was less common.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

Chen

Shang

et al. 2023

Vaccines

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness. However, vaccines are associated with the risk of neurological complications ranging from mild to severe. Severe complications such as vaccine-induced immune thrombotic thrombocytopenia (VITT) associated with acute ischaemic stroke have been reported as rare complications post-COVID-19 vaccination. During the pandemic era, VITT evaluation is needed in cases with a history of vaccination within the last month prior to the event. Cerebral venous sinus thrombosis (CVST) should be suspected in patients following immunization with persistent headaches who are unresponsive to analgesics. In this article, we investigated neurological complications after COVID-19 vaccination and provided more subsequent related clinical studies of accurate diagnosis, pathophysiological mechanisms, incidence, outcome, and management.

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“…In fingolimod-treated patients, attention should be paid to the presence of lymphopenia [72]. In NMOSD patients, vaccination is also safe and not associated with disease progression [73]. Patients treated with rituximab showed a poorer response, and could be at risk of infection despite vaccination [74].…”

Section: Covid-19 Vaccination In Patients With Neuroimmune Disordersmentioning

confidence: 99%

“…Patients treated with rituximab showed a poorer response, and could be at risk of infection despite vaccination [74]. In MG cases, vaccination theoretically may cause disease exacerbation, but patients with MGFA I and II should not avoid vaccination [73,74]. Qualification for vaccination in other cases should be done on an individual basis, bearing in mind that the benefits outweigh the risks in most patients [77].…”

Section: Covid-19 Vaccination In Patients With Neuroimmune Disordersmentioning

confidence: 99%

COVID-19 and autoimmune diseases of the nervous system — an update

Morawiec

Adamczyk

Adamczyk-Sowa

2023

Neurol Neurochir Pol.

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Introduction. Due to a similar pathomechanism, COVID-19 infection may significantly affect the course of autoimmune diseases (AIDs). In our review, we aimed to assess the severity of SARS-CoV-2 infection, response to treatment, and the impact of COVID-19 infection on the course of the underlying disease in patients with neuroimmune diseases.State of the art. In the time of the COVID-19 pandemic, it was important to determine the influence of COVID-19 infection on the course of autoimmune diseases due to the weakened immune system and immunosuppressive therapies.Clinical implications. Many reports have indicated that in patients with AIDs, the existence of the disease is not associated with a worse prognosis in the course of the viral infection. Patients in advanced stages of the disease, elderly patients, and those with comorbidities are at risk of more frequent hospitalisations and higher mortality in the course of COVID-19. Moreover, some drugs used in AIDs have been tested for their efficacy in SARS-CoV-2 infection. Episodes of newly diagnosed myasthenia gravis, Guillain-Barré syndrome, acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica spectrum disorder (NMOSD) secondary to COVID-19 or vaccination have also been reported. Vaccination against this pathogen is highly recommended in most patients with AIDs. Future directions. Despite many studies on the association between COVID-19 and neuroimmune diseases, more specific data is needed. The approach to patients with AIDs should be individual, since many issues remain unresolved despite the long-lasting pandemic.

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Watch out for neuromyelitis optica spectrum disorder onset or clinical relapse after COVID-19 vaccination: What neurologists need to know?

Cited by 7 publications

References 38 publications

Optic neuritis associated with COVID-19-related vaccines

Optic neuritis associated with COVID-19-related vaccines

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

COVID-19 and autoimmune diseases of the nervous system — an update

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