Water and Aqueous Mixtures as Convenient Alternative Media for Organoselenium Chemistry

Abstract

Abstract:Even if water is the natural environment for bioorganic reactions, its use in organic chemistry is often severely limited by the high insolubility of the organic derivatives. In this review, we introduce some examples of the use of water to perform organoselenium chemistry. We mainly discuss the advantages of this medium when the recyclability is demonstrated and when the water can control the selectivity of a reaction or enhance the reaction rate.

Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds

“…Selenium organic compounds are related in a broader context of applications [ 82 , 83 , 84 ] and selenium is a fundamental component of the living cells of a variety of organisms [ 85 ]. Based on these features, the use of 77 Se-NMR spectroscopy emerged as an opportunity for structure and reactivity studies [ 86 ].…”

Fluoxetine scaffold to design tandem molecular antioxidants and green catalysts

“…39 Since selenides are largely used in organic synthesis to catalyze oxidation in presence of H 2 O 2 , combined experimental and theoretical mechanistic studies on model organoselenides are important also for designing selenium based organocatalysts. [40][41][42][43][44][45] The rationale that guided the design of the seleniumcontaining analogues of uoxetine aims to combine the antioxidant radical scavenging capacity, within the CNS, of the parent compound with the GPx-like activity of organic selenides in a water-soluble drug-like small molecule (tandem antioxidant). Thus, selenouoxetine and its derivatives here reported represent models for the experimental and theoretical investigation of their elementary, but biologically as well as chemically signicant, reaction with H 2 O 2 .…”

Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII

“…Organo-chalcogenide scaffolds are topics of intense research in many fields of medicinal chemistry in the last decades. [1][2][3] Selenium and sulfur have been demonstrated to play an important role in biological systems as part of the active site in many proteins 4,5 and their organo-derivatives can be employed as antioxidant 6 , antimicrobial 7 , and antitumor agents. 8 These therapeutic agents also act as modulators on a variety of enzyme such as nitric oxide synthase (NOS), 9 inosine monophosphate dehydrogenase (IMDPH) 10 , lipoxygenases (LOX) 11 and more recently, as carbonic anhydrase (CA, E.C.…”