Water and Electrolyte Salvage in an Animal Model of Dehydration and Malnutrition

Islam, Samia; Abély, M.; Alam, Navshad; Dossou, Flore; Chowdhury, Ashish K.; Desjeux, Jehan-François

doi:10.1097/00005176-200401000-00009

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…Also, a CEN solution has variance on the parameters investigated. Differences in been used to maintain the hydration status of humans osmolality (from 12.3-222.3) and pH (7.85-8.38) among and animals (Islam et al, 2004) and an in ovo injection all the treatment solutions tested did not affect any of the solution containing a combination of 1:400 CEN and 5.5 parameters examined in this study. These results were mM KCl has proved to be safe for chicks during the 0 to similar with those of a previous study which has shown 10 d post-hatch period (McGruder et al, 2011a).…”

Section: Resultsmentioning

confidence: 76%

Effects of in ovo Injection of Theophylline and Electrolyte Solutions on Hatchability and Growth of Broilers from Day 0 to Day 10 Post-Hatch

McGruder

Zhai

Keralapurath

et al. 2011

International J. of Poultry Science

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The in ovo feeding of supplemental nutrients, electrolytes and stimulants during late embryogenesis has the potential of benefitting subsequent broiler performance. Therefore, the effects of the automated in ovo injection of 200 µL of a 1:400 carbohydrate/electrolyte nutrient solution, 5.0 m M tripotassium citrate, or 1.0 mM creatine in combination with 5.5 mM potassium chloride and 1.0 mM theophylline solution on hatchability and post-hatch performance of Ross x Ross 308 broilers were investigated. Non-injected and 117 mM saline-injected controls were included. All 5 treatment groups, each containing 20 eggs, were equally represented on each of 4 replicate tray levels in a single incubator. All eggs were incubated under standard incubation conditions with incubator dry and wet bulb temperature set at 37.6 and 29.0°C, respectively. Treatment solutions were injected into the amnion of embryos on d 18 of incubation. After hatch, chicks were brooded under standard commercial grow-out conditions. Hatchability; BW on d 0 (d of hatch), 3 and 10 post-hatch; d 3 yolk sac weight and yolk sac moisture concentration and post-hatch mortality were not affected by any injection treatments. Plasma refractive index decreased and liver moisture concentration of broiler progeny increased between d 3 and 10 post-hatch; however, no treatment effects on either parameter were observed. The current study indicated that the tested stimulant solutions had no detrimental effects on broiler hatchability or post-hatch performance, suggesting their potential use alone or in combination in the commercial injection of broiler hatching eggs to improve growth and post-hatch broiler performance.

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Section: Resultsmentioning

confidence: 76%

Effects of in ovo Injection of Theophylline and Electrolyte Solutions on Hatchability and Growth of Broilers from Day 0 to Day 10 Post-Hatch

McGruder

Zhai

Keralapurath

et al. 2011

International J. of Poultry Science

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“…A rise in blood creatinine levels is observed with marked damage to functioning nephrons (15). Furthermore, the most common cause of an elevated blood urea nitrogen concentration is due to a condition such as dehydration or malnutrition (16, 17). Therefore, our findings might demonstrate that older adults who are dehydrated showed highly elastic saliva, which was associated with renal function.…”

Section: Discussionmentioning

confidence: 99%

Serum markers of chronic dehydration are associated with saliva spinability

et al. 2007

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Findings of a relationship between saliva and dehydration have been observed, but the precise nature of these relationships is unclear and no evidence of a direct link has been found. In particular, no study reports a relationship between chronic dehydration and saliva conditions in community-dwelling older adults. This study aimed to identify whether salivary conditions are sensitive to body hydration markers in an elderly population. A total of 403 subjects aged 76 years participated in the study. Stimulated saliva flow rate and spinability of saliva were measured. In addition, determinations of serum levels of uric acid, blood urea nitrogen (BUN), creatinine, sodium and potassium were made. Dehydration was defined as uric acid >/= 7 mg dL(-1) according to the standard value. The salivary spinability were significantly associated with the concentration of uric acid (OR=2.06, P=0.044) according to multiple logistic regression analysis. In addition, after adjusting for gender, the uric acid concentration and the salivary spinability was significantly associated with BUN, potassium and creatinine levels. The subjects with high uric acid levels (>/= 7 mg dL(-1)) had the most elastic saliva. Both BUN and serum creatinine are the most commonly used indicators of renal function. Therefore, our findings might demonstrate that older adults who are dehydrated showed highly elastic saliva, which was associated with renal function. In conclusion, this study suggests that there is a significant relationship between chronic dehydration status and salivary spinability level.

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“…Thus, it is possible that renin expression was affected by the age in the older rabbits in this study. Nevertheless, the rabbits in both groups were systemically dehydrated based on imposed water restriction and decreased body weight, which is commonly used as a consistent indicator of dehydration in humans [ 86 – 88 ] and animal models [ 28 , 30 , 89 – 92 ]. Clinical translation to human subjects is preliminary and awaits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis reveals that aging rabbit vocal folds are more vulnerable to changes caused by systemic dehydration

Nascimento¹,

Bailey²,

Santos³

et al. 2022

BMC Genomics

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Background Older adults are more prone to develop systemic dehydration. Systemic dehydration has implications for vocal fold biology by affecting gene and protein expression. The objective of this study was to quantify vocal fold protein changes between two age groups and hydration status, and to investigate the interaction of age and hydration status on protein expression, which has not been investigated in the context of vocal folds before. Comparative proteomics was used to analyze the vocal fold proteome of 6.5-month-old and > 3-year-old rabbits subjected to water ad libitum or water volume restriction protocol. Results Young and older adult rabbits (n = 22) were either euhydrated (water ad libitum) or dehydrated by water volume restriction. Dehydration was confirmed by body weight loss of − 5.4% and − 4.6% in young and older groups, respectively, and a 1.7-fold increase of kidney renin gene expression in the young rabbits. LC-MS/MS identified 2286 proteins in the rabbit vocal folds of young and older adult rabbits combined. Of these, 177, 169, and 81 proteins were significantly (p ≤ 0.05) affected by age, hydration status, or the interaction of both factors, respectively. Analysis of the interaction effect revealed 32 proteins with opposite change patterns after dehydration between older and young rabbit vocal folds, while 31 proteins were differentially regulated only in the older adult rabbits and ten only in the young rabbits in response to systemic dehydration. The magnitude of changes for either up or downregulated proteins was higher in the older rabbits. These proteins are predominantly related to structural components of the extracellular matrix and muscle layer, suggesting a disturbance in the viscoelastic properties of aging vocal fold tissue, especially when subjected to systemic dehydration. Conclusions Water restriction is a laboratory protocol to assess systemic dehydration-related changes in the vocal fold tissue that is translatable to human subjects. Our findings showed a higher number of proteins differentially regulated with a greater magnitude of change in the vocal folds of older adult rabbits in the presence of systemic dehydration compared to younger rabbits. The association of these proteins with vocal fold structure and biomechanical properties suggests that older human subjects may be more vulnerable to the effects of systemic dehydration on vocal function. The clinical implications of these protein changes warrant more investigation, but age should be taken into consideration when evaluating vocal treatment recommendations that interfere with body fluid balance.

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Water and Electrolyte Salvage in an Animal Model of Dehydration and Malnutrition

Cited by 7 publications

References 19 publications

Effects of in ovo Injection of Theophylline and Electrolyte Solutions on Hatchability and Growth of Broilers from Day 0 to Day 10 Post-Hatch

Effects of in ovo Injection of Theophylline and Electrolyte Solutions on Hatchability and Growth of Broilers from Day 0 to Day 10 Post-Hatch

Serum markers of chronic dehydration are associated with saliva spinability

Proteomic analysis reveals that aging rabbit vocal folds are more vulnerable to changes caused by systemic dehydration

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