Water balance during saline imbibition in the mongolian gerbil (meriones unguiculatus)

Edwards, B. A.; Peters, Alison R

doi:10.1016/0300-9629(88)91010-9

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Introduction to experimental design and use of primary literature. The second lab unit, on renal physiology, investigates osmoregulation in gerbils and was initially developed around a set of core papers from the primary literature on salt and water balance in gerbils (2,3). This lab unit is probably the most important one of the semester, because it models a more sophisticated type of investigative inquiry expected of student-designed experiments in this course (i.e., going beyond the DYO of introductorylevel courses).…”

Section: Guided Inquiry As a Model For Investigative Labsmentioning

confidence: 99%

“…The intent here is to model the practice of using the primary literature for corroboration and comparison. To answer the question of whether gerbils drinking 2% saline (0.34 M) secrete ADH to concentrate their urine, I direct students to Table 2 of the Edwards and Peters paper (3), which shows that gerbils drinking 0.25 M saline store increased amounts of neurohormones in the posterior pituitary, indicative of synthesis but not release of ADH, whereas gerbils drinking higher concentrations of saline (0.5-1.0 M) exhibit reduced neurohormone content of the posterior pituitary, suggestive of ADH release. I leave it up to the students to conclude whether the gerbils in their study (drinking saline whose molarity is between the two solutions tested in the Edwards and Peters study) show evidence of ADH secretion or not.…”

Section: Guided Inquiry As a Model For Investigative Labsmentioning

confidence: 99%

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Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

Chaplin

2003

Advances in Physiology Education

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Student-originated projects are increasingly utilized in the biology laboratory as a means of engaging students and revitalizing the laboratory experience by allowing them one to two weeks to collect data on a manipulated variable of their choice by use of an introduced technique. Such experiments fail as good models of investigative learning when they place more emphasis on novel ideas than on hypothesis testing, experimental design, statistical rigor, or use of the primary literature. In addition, students get used to the routine and tend to design the same type of simplistic experiments in each course unless challenged. Laboratories in a Comparative Anatomy and Physiology course at the University of St. Thomas were reorganized to encourage the development of investigative skills in a stepwise fashion throughout the semester. Initial labs concentrated on experimental design and statistical analysis, then use of the primary literature in interpretation of the data was emphasized, and finally, students were asked to design their experiments and analyze their data on the basis of models from the primary literature.

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Section: Guided Inquiry As a Model For Investigative Labsmentioning

confidence: 99%

Section: Guided Inquiry As a Model For Investigative Labsmentioning

confidence: 99%

Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

Chaplin

2003

Advances in Physiology Education

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Cardiac Natriuretic Peptide Response to Water Restriction in the Hormonal Adaptation of Two Semidesert Rodents from West Africa (Steatomys caurinus, Taterillus gracilis)

Lacas

Allevard

Ag'Atteinine

et al. 2000

General and Comparative Endocrinology

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Kidney concentrating ability of a subterranean xeric rodent, the naked mole-rat (Heterocephalus glaber)

Urison

Buffenstein

1994

J Comp Physiol B

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The naked mole-rat (Heterocephalus glaber) is a strictly subterranean mammal inhabiting the arid zones of north-east Africa. These animals have no access to free water and water balance thus might be facilitated by regulating renal water loss. The urinary concentrating ability of the naked mole-rat was determined using five dietary manipulations in which both water and salt content were altered. "Control" animals (n = 7) received a high quality protein cereal mixed to a thin paste with water (1 g cereal: 8.5 g water). Water stress was induced by reducing the water content of the diet by either 50% (n = 7) or 65% (n = 7). Salt loading was facilitated by replacing the water with the same volume of either 0.9% salt (n = 7) or 3.0% salt (n = 4) solutions. Changes in body mass, food consumption and urine volume were measured daily. The effect of diet on osmolality and electrolyte concentrations of urine and plasma were determined on termination of the diet trials. Although energy intake was not reduced, naked mole-rats lost body weight with both water stress treatments. Urine volume voided per day decreased significantly with both water stress treatments (P < 0.05), such that the most extreme water stress led to an 80% reduction in urine volume. Mildly salt-loaded animals gained weight, yet underwent a sodium diuresis, as indicated by a 1.3-fold increase in the daily volume of urine voided (P < 0.05). Maximum urine concentration (1521 +/- 250 mmol.kg-1) was achieved with mild water stress and was 4.6 +/- 0.9 times that of plasma.(ABSTRACT TRUNCATED AT 250 WORDS)

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Water balance during saline imbibition in the mongolian gerbil (meriones unguiculatus)

Cited by 6 publications

References 13 publications

Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

Cardiac Natriuretic Peptide Response to Water Restriction in the Hormonal Adaptation of Two Semidesert Rodents from West Africa (Steatomys caurinus, Taterillus gracilis)

Kidney concentrating ability of a subterranean xeric rodent, the naked mole-rat (Heterocephalus glaber)

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