Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes <i>via</i> electrospinning

Castro, Karine Cappuccio de; Burga-Sánchez, Jonny; Campos, Maria Gabriela Nogueira; Mei, Lucía Helena Innocentini

doi:10.1039/d0ra04950f

Cited by 17 publications

(14 citation statements)

References 28 publications

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“…On the other hand, this increase in absorption might be related to the presence of a polar group in the crosslinker. In a previously published study, we showed that membranes had similar behavior in swelling tests, corroborating with this result . The results showed that the swelling behavior in the first 12 h for the 15 wt % MA membrane increased by 501%, while for 30 wt % MA, it increased by 296%.…”

Section: Resultssupporting

confidence: 89%

“…Finally, crosslinking was evidenced by the peak at 1700 cm –1 , which corresponds to the existence of the −COO– elongation, and by the change in the intensity at the peak of 1091 cm –1 , which is also related to the crosslinking between the −OH group of the structure of the PVA and the −CO grouping of the MA molecule, giving rise to the −COC– band. − Still, another interesting observation was the disappearance of the peak at 1640 cm –1 , related to the −CC– bond of the MA molecule, suggesting its presence in the photocrosslinking reaction. , …”

Section: Resultsmentioning

confidence: 98%

“…In a previously published study, we showed that membranes had similar behavior in swelling tests, corroborating with this result. 24 The results showed that the swelling behavior in the first 12 h for the 15 wt % MA membrane increased by 501%, while for 30 wt % MA, it increased by 296%. However, after 24 h, the 30 wt % MA membrane reached about 550% swelling, which is more significant than the 15 wt % MA membrane (∼450%), and it was maintained for up to 72 h. While after 72 h, the 15 wt % MA membrane started to show a decrease in the swelling rate (∼380%), suggesting weight loss, that is, membrane disintegration.…”

Section: Optical Microscopymentioning

confidence: 94%

“…22−24 Still, another interesting observation was the disappearance of the peak at 1640 cm −1 , related to the −C�C− bond of the MA molecule, suggesting its presence in the photocrosslinking reaction. 24,25…”

Section: Impact Of Maleic Anhydride On the Physicalmentioning

confidence: 99%

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Hyaluronic Acid/Polyvinyl Alcohol Electrospun Nanofiber Membranes Loaded with Plantago Major Extract for Smart Wound Dressings

Castro

Silva

Campos

et al. 2022

ACS Appl. Nano Mater.

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Electrospinning has stood out as a promising technique for producing innovative dressings. In this regard, this study aimed to evaluate the effect of crosslinking with maleic anhydride (MA) at 0, 15, and 30 wt % on the morphological, physicochemical, and thermal properties and storage stability of electrospun hyaluronic acid /polyvinyl alcohol membranes loaded with Plantago major extract. The crosslinking enhanced the manufacturing process of the membranes. It reduced the average diameter of crosslinked nanofibers with 30 wt % MA by about 20 nm and increased the maximum decomposition temperature by 12 °C compared to control samples. Furthermore, crosslinking prevented the phase separation of the blend, making the crosslinked membranes more homogeneous. The storage stability results indicated that lower relative humidities favored the maintenance of the physical structure of the membranes, and the sorption isotherms obtained by the experimental data were better fitted by the Guggenheim−Anderson−de Boer model. This investigation suggested a promising approach to designing new wound healing dressings.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 98%

Section: Optical Microscopymentioning

confidence: 94%

Section: Impact Of Maleic Anhydride On the Physicalmentioning

confidence: 99%

See 2 more Smart Citations

Hyaluronic Acid/Polyvinyl Alcohol Electrospun Nanofiber Membranes Loaded with Plantago Major Extract for Smart Wound Dressings

Castro

Silva

Campos

et al. 2022

ACS Appl. Nano Mater.

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“…[65] In addition, a method for manufacturing nanofiber dressings using a photo-crosslinking process without employing an organic solvent was also studied. [66] Table 3 presents recent approaches of composite materials used to improve the properties of dressings applied to hydrogels and nanofiber dressings based on PVA-HA.…”

Section: Type Composite Materials Materials Characteristicmentioning

confidence: 99%

Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

Jin

2022

Chemistry An Asian Journal

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The development of ideal wound dressing with excellent properties, such as exudate absorption capacity, drug release control ability, and increased wound healing, is currently a major requirement for wound healing. Polyvinyl alcohol (PVA) is a biodegradable semi‐crystalline synthetic polymer that has been used in the field of biotechnology such as tissue regeneration, wound dressing, and drug delivery systems. In recent years, PVA‐based wound dressing materials have received considerable attention due to their excellent properties such as biodegradability, biocompatibility, non‐toxicity and low cost. PVA can be used as a wound dressing material to create the necessary moist wound environment, improve the physical properties of the dressing, and increase the wound healing rates. In addition, PVA can also be mixed with other organic and inorganic materials and can be used for drug delivery and wound healing. This review article addresses the role of biomaterials based on PVA mixed with other ingredients for wound dressing. It also focuses on its recent use in wound dressings as carriers of active substances.

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Water‐soluble astaxanthin and silver enriched poly(vinyl alcohol)/silk fibroin crosslinking electrospun nanofiber for wound dressing

Mai,

Wang,

Gong

et al. 2024

J of Applied Polymer Sci

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The aim of this work is to fabricate a novel electrospun poly(vinyl alcohol) (PVA)/silk fibroin (SF) nanofibrous membrane containing astaxanthin (ASTA) and silver (Ag) nanoparticles as potential wound dressing. Since ASTA is typically liposoluble, the bioavailability could be greatly enhanced by improving its hydrophilicity. The antioxidant performance of eletrospun membrane is verified by ABTS radical scavenging assays. The beadless fibers could be fabricated at 16 kV when PVA (12, wt%) is blended with SF (6, wt%). In addition, the membrane is carefully chemically crosslinked by comparing the efforts (i.e., mechanical strength and water resistance) of glutaraldehyde dipping and vapor treatment. The morphology of the electrospun membrane is observed by scanning electron microscopy and optical microscope. The formation of Ag nanoparticles, which provides the membranes antibacterial properties, is also confirmed by energy dispersive spectroscopy and inhibition zone test. Meanwhile, the PVA/SF/ASTA/Ag compound membrane is characterized by Fourier transform infrared spectroscopy, x‐ray diffraction, thermo gravimetric analysis, differential thermal analysis, and water contact angle. The releasing of ASTA is also measured, and kinetic data are adjusted by Higuchi models. Finally, the biocompatibility is confirmed by in vitro cell staining experiments and in vivo rat models.

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Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes via electrospinning

Abstract: Homogeneous nanofibers and non-cytotoxic HA/PVA membranes were produced by conventional electrospinning method followed by photocrosslinking process, without using any organic solvent. The membranes showed great potential for biomedical applications.

Cited by 17 publications

References 28 publications

Hyaluronic Acid/Polyvinyl Alcohol Electrospun Nanofiber Membranes Loaded with Plantago Major Extract for Smart Wound Dressings

Hyaluronic Acid/Polyvinyl Alcohol Electrospun Nanofiber Membranes Loaded with Plantago Major Extract for Smart Wound Dressings

Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

Water‐soluble astaxanthin and silver enriched poly(vinyl alcohol)/silk fibroin crosslinking electrospun nanofiber for wound dressing

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