Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario)

Hoeger, Birgit; Köllner, Bernd; Dietrich, Daniel R.; Hitzfeld, Bettina C.

doi:10.1016/j.aquatox.2005.07.006

Cited by 307 publications

(146 citation statements)

References 23 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…For a concentration of 5 µg L −1 renal lesions were evident as well as drug bioaccumulation in the liver, kid-neys, gills and muscle [66,67]. Brown trout (Salmo trutta f. fario) showed similar cytological damage and a reduction of haematocrit values after 21 days of exposure to 0.5 µg L −1 of this active sub-stance [68]. Schmitt-Jansen et al [69] evaluated both diclofenac phytotoxicity and its photochemical products on the unicellular chlorophyte Scenedesmus vacuolatus.…”

Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 95%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

View full text Add to dashboard Cite

Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

show abstract

Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 95%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

View full text Add to dashboard Cite

show abstract

“…[7][8][9] All AOPs are based on the in situ generation of highly reactive and shortlived reactive oxygen species such as HO , H 2 O 2 , O 3 and O 2 water bodies, [16,17] groundwater aquifers [18] and WWTP effluents [19] and its toxic effects on aquatic and terrestrial organisms. [20,21] In particular, DCF has displayed the highest acute toxicity in comparison to other NSAIDs. [22] A concentration of 11 454 mg L À1 was reported to cause 50 % of effect (EC 50 ) on the Microtox system over 30 min.…”

Section: Introductionmentioning

confidence: 99%

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Kanakaraju¹,

Cherie²,

Motti³

et al. 2014

Environ. Chem.

View full text Add to dashboard Cite

Environmental context. Diclofenac, a common non-steroidal anti-inflammatory drug, is not completely removed from surface and drinking water by conventional treatment methods. Consequently, this drug is present in the aquatic environment and has been subsequently linked to toxic effects on organisms. We show that photolysis and TiO 2 -catalysed degradation in circulating batch reactors efficiently results in diclofenac removal under a variety of conditions. These photochemical methods thus may lead to more effective water treatment processes.Abstract. The occurrence of diclofenac (DCF) as an emerging pollutant in surface waters and drinking water has been attributed to elevated global consumption and the inability of sewage treatment plants to remove DCF. In this study, DCF spiked drinking water and river water was subjected to photolysis and TiO 2 photocatalytic treatments in a circulating laboratory-scale (immersion-well) and a demonstration-scale loop reactor (Laboclean). The operational parameters for the immersion-well reactor were optimised as follows: TiO 2 P25 loading, 0.1 g L À1 ; natural pH, 6.2; initial concentration, 30 mg L À1 ; water type, distilled water. Complete DCF removal was realised within 15 min under the optimised conditions using the immersion-well reactor. Sunlight-mediated photochemical degradation required a prolonged exposure period of up to 360 min for complete DCF removal. DCF in distilled and drinking water was efficiently degraded in the larger Laboclean reactor. Differences were, however, observed based on their pseudo-first-order rate constants, which implies that the water matrix has an effect on the degradation rate. Six major photoproducts, 2-(8-chloro-9H-carbazol-1-yl)acetic acid, 2-(8-hydroxy-9H-carbazol-1-yl)acetic acid, 2,6-dichloro-N-o-tolylbenzenamine, 2-(phenylamino)benzaldehyde, 1-chloromethyl-9H-carbazole and 1-methyl-9H-carbazole, generated from TiO 2 photocatalysis of DCF were identified by liquid chromatography-mass spectrometry (LCMS) and Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS). This work has shown that photocatalytic degradation kinetics of DCF are dependent on both the geometry of the photoreactor and the nature of the water matrices.

show abstract

“…DCF has previously been shown to adversely affect various tissues in patients, including the gastro-intestinal tract, the liver and the kidney (Atchison et al, 2000;Banks et al, 1995;Hickey et al, 2001). Recently, adverse effects of DCF, such as accumulation of protein droplets in the kidney and gill pathology have been reported in rainbow trout (Oncorhynchus mykiss) Triebskorn et al, 2004) and brown trout (Hoeger et al, 2005) following sub-acute to sub-chronic exposure.…”

mentioning

confidence: 99%

Distribution of intraperitoneally injected diclofenac in brown trout (Salmo trutta f. fario)

Hoeger

Dietrich

Schmid

et al. 2008

Ecotoxicology and Environmental Safety

Self Cite

View full text Add to dashboard Cite

The detection of low levels of pharmaceuticals in aquatic environments has lately raised concerns regarding possible adverse effects of these highly active substances on aquatic organisms. The non steroidal anti inflammatory drug diclofenac (DCF) is one of the pharmaceutical substances regularly detected in surface waters and has lately been demonstrated to elicit adverse effects in salmonid species at environmentally relevant concentrations. The aim of the present study was to investigate the distribution of DCF in indigenous brown trout (Salmo trutta f. fario) following intraperitoneal (i.p.) injection of a single dose of 14 C labelled DCF. A distribution kinetic over 36 h provides information on possible accumulation of DCF in different organs as well as on DCF detoxification in trout, possibly enabling identification of sites of preferential toxicity. Approximately 57% of the total single DCF dose appeared in the bile 6 h after i.p. application. Subsequently, DCF was observed to undergo enterohepatic cycling with an amount of 14 C activity comparable to the 6 h bile values reappearing in bile 36 h after application. Results for 14 C activity in intestine and pylori support the observation of enterohepatic cycling with a small peak in intestine at 3 h post i.p. injection and a low peak in intestine and pylori at 6 h post i.p. injection, reflecting presence of the drug substance in bile. The highest activity in intestine was found 24 h post injection coinciding with low levels in bile, followed by a gradual decrease of activity in intestine mirroring the re uptake of DCF into bile. The finding of enterohepatic cycling of DCF in brown trout is suggestive of a prolonged retention of DCF in brown trout.

show abstract

Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario)

Cited by 307 publications

References 23 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Distribution of intraperitoneally injected diclofenac in brown trout (Salmo trutta f. fario)

Contact Info

Product

Resources

About