Water-Clear Cell Parathyroid Adenoma Causing Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Report of a Case

Kodama, Hitoshi; Iihara, Masatoshi; Okamoto, Takahiro; Obara, Takao

doi:10.1007/s00595-007-3484-x

Cited by 30 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the reports describes parathyroid adenoma as the cause of hyperparathyroidism (16)(17)(18)(19). We found one case report of the association between NF1 and parathyroid carcinoma (20).…”

Section: Discussionmentioning

confidence: 99%

Association between atypical parathyroid adenoma and neurofibromatosis

Favere

Tsukumo

Matos

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Association between atypical parathyroid adenoma and neurofibromatosis

Favere

Tsukumo

Matos

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

“…In 1 patient, there was concomitant multiple endocrine neoplasia type 1 (MEN-1); in 1 patient, neurofibromatosis type 1 (NF-1); and in all others, it was found to be sporadic. The most common adenoma localization was the left inferior parathyroid gland (n=10), followed by the right lobe upper pole (n=4) (4,12). In 1 patient, the lesion was reported to be located in the left thyroid lobe (8).…”

Section: Literature Reviewmentioning

confidence: 99%

“…The rare form (1%) of water-clear cell hyperplasia (WCCH) of hyperparathyroidism was first described by Albright et al (3) in 1934. As adenoma in the etiology is even more uncommon, only 19 cases have been reported since 1994, and of those cases, adenoma was in both parathyroid glands in only one case (1,2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma

et al. 2017

View full text Add to dashboard Cite

An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma INTRODUCTIONPrimary hyperparathyroidism is one of the most encountered endocrine pathologies, with an incidence of 21.6/100,000. In the etiology, the leading cause is solitary adenoma (87%-91%), generally originating from chief cells (1). Adenoma originating from more than one gland is a rarer event and comprises 2%-15% of all adenomas (2). The rare form (1%) of water-clear cell hyperplasia (WCCH) of hyperparathyroidism was first described by Albright et al. (3) in 1934. As adenoma in the etiology is even more uncommon, only 19 cases have been reported since 1994, and of those cases, adenoma was in both parathyroid glands in only one case (1,2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).Hypercalcemic crisis, which was first described by Hannas in 1939, is a severe and life-threatening condition of severe hypercalcemia progressing to associated failure of various systems (21). Of the known cases, the case reported here is the first of hypercalcemic crisis caused by water-cell clear adenoma (WCCA). In previous reports related to WCCA, the histopathological features of the disease have generally been the focus. The aim of this study was to present the preoperative and postoperative periods of the disease and to evaluate the clinical characteristics. Defining the clinical characteristics of these kinds of rare cases can be considered useful for clinicians.In this case report, we present a patient who was successfully treated for double WCCA, and the case is discussed in comparison with the 19 cases reported in literature. Objective: To evaluate the clinical characteristics of a patient operated for water-clear cell adenoma and to discuss these in the light of relevant literature. MATERIAL AND METHODS Material and Methods:PubMed and Google Scholar were searched to identify articles related to water-clear cell adenoma using the following keywords: parathyroid tissue, parathyroid gland, parathyroid cells, parathyroid adenoma, parathyroid hyperplasia, water-clear-cell, and water clear cell. The search included case reports, review articles, and original articles that had been published between January 1990 and November 2014 without any restrictions on language. All articles that contained information on the study population and treatment related data were identified and retrieved. In addition, an evaluation was of a case of a 47-year-old male patient with PHC who was treated at our clinic was conducted.Results: A total of 19 patients, including our new case, (age range: 18 to 81 years, mean±SD: 57.47±16.31 years) were included in the analysis. Eleven patients were female. Information about adenoma location was available from studies involving 17 patients and they indicated the following distribution of locations: left inferior (n=10), right superior (n=4). When preoperative imaging methods were examined, a false negative result was given by ultrasonography in 28.5% of patients and only 57.1% were positive on scintig...

show abstract

“…Approximately 13 patients with NF1 and HPP have been described, but the pathogenesis of this association has not yet been well elucidated [12]. Dayle et al [6] reported the first cases in the literature, and presented the hypothesis that there could be a genetic link between parathyroid adenoma (originating in endoderm) and NF1 (originating in neuroectoderm).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Remission of Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Case Report

MM¹

2012

J Clin Case Rep

View full text Add to dashboard Cite

Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder affecting approximately 1 in 3500 individuals. Patients with the disorder can develop carcinoid tumors, medullary thyroid carcinoma, pheochromocytoma and tumor of the hypothalamus. The association of NF1 with Primary Hyperparathyroidism (HPP) is very rare. We report a 56-year-old woman with NF1 who was referred to our service because of nephrolithiasis. Physical examination revealed the characteristic signs of NF1, and her laboratory calcium profile was compatible with HPP. The patient was referred for parathyroidectomy, but during the surgical work-up she underwent spontaneous remission of her HPP. This case is significant not only for the rarity of this presentation in NF1 patients, but also because of the spontaneous remission of HPP.

show abstract

Water-Clear Cell Parathyroid Adenoma Causing Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Report of a Case

Cited by 30 publications

References 11 publications

Association between atypical parathyroid adenoma and neurofibromatosis

Association between atypical parathyroid adenoma and neurofibromatosis

An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma

Spontaneous Remission of Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Case Report

Contact Info

Product

Resources

About