Water Consumption of the Ageing Sprague-Dawley Male Rat

Osborn, G. K.; Jones, D. G.; Kimeldorf, Donald J.

doi:10.1159/000211107

Cited by 13 publications

(5 citation statements)

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“…Differences in ad libitum intakes between young and old rats seem to depend on strain and whether intakes are adjusted for body weight. There are reports of increased daily water intakes in old Wistar (16) , F344 (4, 30, 34), and SD rats (14,22,30) compared with the young animals of these strains. Others report equivalent daily water intakes between young and old Lewis (35) or Wistar rats (36) and decreased daily water intakes in old F344 ϫ BN rats (33).…”

Section: Discussionmentioning

confidence: 99%

“…However, there are only a few studies in aging rats investigating the capacities of behavioral systems, namely, thirst and salt appetite, to supply sufficient water and sodium to maintain adequate hydration. Investigators variously report that old rats have diminished (14,23,33), increased (4,14,16,22), or unchanged (35,36) daily intakes of water compared with young cohorts. Compared with young rats, old rats reportedly drink equivalent (30) or smaller (33) amounts of water in response to water deprivation and exogenously administered ANG II.…”

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confidence: 99%

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Thirst and salt appetite responses in young and old Brown Norway rats

Thunhorst

Johnson²

2003

American Journal of Physiology-Regulatory, Integrative and Comp

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Thunhorst, Robert L., and Alan Kim Johnson. Thirst and salt appetite responses in young and old Brown Norway rats. Am J Physiol Regul Integr Comp Physiol 284: R317-R327, 2003. First published October 10, 2002 10.1152/ ajpregu.00368.2002 Norway rats aged 4 mo (young) and 20 mo (old) received a series of experimental challenges to body fluid homeostasis over ϳ3 mo. Water was available for drinking in some tests, and both water and 0.3 M NaCl were available in others. The series included three episodes of extracellular fluid depletion (i.e., furosemide ϩ 20 h of sodium restriction), two tests involving intracellular fluid depletion (i.e., hypertonic saline: 1 or 2 M NaCl at 2 ml/kg body wt sc), one test involving overnight food and fluid restriction, and testing with captopril adulteration of the drinking water (0.1 mg/ml) for several days. Old rats were significantly heavier than young rats throughout testing. Old rats drank less water and 0.3 M NaCl after sodium deprivation than young rats, in terms of absolute and body weightadjusted intakes. Old rats drank only half as much water as young rats in response to subcutaneous hypertonic NaCl when intakes were adjusted for body weight. Old rats drank less 0.3 M NaCl than young rats after overnight food and fluid restriction when intakes were adjusted for body weight. In response to captopril adulteration of the drinking water, young rats significantly increased daily ingestion of 0.3 M NaCl when it was available as an alternative to water and significantly increased daily water intakes when only water was available, in terms of absolute and body weight-adjusted intakes. Old rats had no response to captopril treatment. These results add important new information to previous reports that aging rats have diminished thirst and nearabsent salt appetite responses to regulatory challenges. aging; drinking; diuresis; natriuresis; dehydration; hypovolemia ELDERLY HUMANS CONSUME ADEQUATE fluids on a daily basis (7). Yet dehydration is a major health risk for the elderly (5), and the elderly are susceptible to dehydration because of increased fluid losses (41). Aged kidneys have a decreased ability to concentrate urine (17, 27) and to conserve sodium (8), along with a relative resistance to vasopressin (25), and release less renin when challenged (6). These changes with age predispose the elderly to hypovolemia and dehydration because of the reduced ability to conserve water and sodium during times of relative water and sodium loss. The elderly have decreased thirst sensation (24, 26, 32). As a result, they are slower than young people to restore fluid balance after exercise-induced dehydration (19) and water deprivation (26). It thus appears that the elderly are more vulnerable to the consequences of physiological challenges to body fluid homeostasis and that diminished thirst in the elderly contributes to their problems of fluid balance (15).The capacities of the aging kidney have been extensively investigated in rat models of aging. As in elderly humans, kidneys of aging r...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Thirst and salt appetite responses in young and old Brown Norway rats

Thunhorst

Johnson²

2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The present evidence concerning this relationship is inconsistent. One study indicated no relationship between age and food intake (Osborn, Jones, & Kimeldorf, 1962), while another indicated a decrease in food intake with increasing age (Everitt, 1958), while still other studies indicated a nonmonotonic function (Farner, 1961a;Kibler & Johnson, 1966;Kibler, Silsby, & Johnson, 1963). All these studies used males as subjects.…”

Section: Consummatory Respondingmentioning

confidence: 99%

“…Normative data on the relationship between water consumption and age are also sparse, but they are more consistent than those on food consumption. Water consumption increased with age as a monotonic function in the rat (Everitt, 1958;Goodrick, 1969b;Kibler et al, 1963;Osborn et al, 1962), and perhaps in the mouse (Goodrick, 1967b). Individual differences in water consumption in the rat also increased with age (Osborn et al, 1962).…”

Section: Consummatory Respondingmentioning

confidence: 99%

“…Water consumption increased with age as a monotonic function in the rat (Everitt, 1958;Goodrick, 1969b;Kibler et al, 1963;Osborn et al, 1962), and perhaps in the mouse (Goodrick, 1967b). Individual differences in water consumption in the rat also increased with age (Osborn et al, 1962). Experimental manipulation of factors that control water intake, such as osmotic pressure and volume of intravascular fluid, should result in a deeper understanding of the mechanisms of these age-related differences in water consumption.…”

Section: Consummatory Respondingmentioning

confidence: 99%

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Age and animal behavior.

Jakubczak¹

1973

The Psychology of Adult Development and Aging.

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My original task was to review the recent literature in the field of comparative psychology of aging. A preliminary search indicated that such a field does not exist. Almost all of the studies reviewed used the white rat as the subject, and no study made a direct comparison across species on behavioral tasks. Consequently, my task became one of reviewing the recent literature in the broader field of animal psychology of aging.There are several reasons for using animal subjects in studies of behavioral aging, as Jerome (1959) pointed out. First, a great deal is known about age-related changes in the anatomy and the physiology of animal subjects. If one wants to test the behavioral implications of these changes, then one should use similar organisms. Second, certain experimental procedures may be carried out with animals that could not be carried out on man because of their danger or discomfort. Third, because of the relatively short life-span of animals and because of the possibility of genetic and experiential control and manipulation over the entire life-span, research with animals should make an important contribution to the understanding of the genetic, physiological, and experiential determinants of age-related changes in behavior. Fourth, if behavioral deterioration with age is a universal phenomenon, it should be found in a broad range of species. And fifth, it is easier to control motivation in animals than in humans. The working assumption in this area is that the basic mechanisms of behavioral aging are similar enough in man and Leonard F. Jakubczak received his PhD in experimental psychology (ger-

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Age differences in the effects of water deprivation on activity, water loss and survival of rats

Jakubczak¹

1970

Life Sciences

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Water Consumption of the Ageing Sprague-Dawley Male Rat

Cited by 13 publications

References 8 publications

Thirst and salt appetite responses in young and old Brown Norway rats

Thirst and salt appetite responses in young and old Brown Norway rats

Age and animal behavior.

Age differences in the effects of water deprivation on activity, water loss and survival of rats

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