2021
DOI: 10.1007/978-3-030-80924-9_1
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Water Contribution to the Protein Folding and Its Relevance in Protein Design and Protein Aggregation

Abstract: Water plays a fundamental role in protein stability. However, the effect of the properties of water on the behaviour of proteins is only partially understood. Several theories have been proposed to give insight into the mechanisms of cold and pressure denaturation, or the limits of temperature and pressure above which no protein has a stable, functional state, or how unfolding and aggregation are related. Here we review our results based on a theoretical approach that can rationalise the water contribution to … Show more

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