Water-Dispersed Single-Wall Carbon Nanohorns as Drug Carriers for Local Cancer Chemotherapy

Murakami, Tatsuya; Sawada, Hirohide; Tamura, Goshu; Yudasaka, Masako; Iijima, Sumio; Tsuchida, Kunihiro

doi:10.2217/17435889.3.4.453

Cited by 75 publications

(46 citation statements)

References 29 publications

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“…The intratumorally administered PEG-DXR-bound oxSWNHs caused a significant retardation in tumor growth associated with the prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates were found from the periphery of the tumor to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport [8].…”

Section: Delivery Of Chemotherapeutic Drugs By Carbon Nanotubessupporting

confidence: 66%

What are carbon nanotubes’ roles in anti-tumor therapies?

Meng

Hua

2010

Sci. China Chem.

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Since their discovery, carbon nanotubes (CNTs) have become one of the most promising nanomaterials in many industrial and biomedical applications. Due to their unique physicochemical properties, CNTs have been proposed and actively exploited as multipurpose innovative carriers for cancer therapy. The aim of this article is to provide an overview of the status of applications, advantages, and up-to-date research and development of carbon nanotubes in cancer therapy with an emphasis on drug delivery, photothermal therapy, gene therapy, RNAi, and immune therapy. In addition, the issues of risk and safety of CNTs in cancer nanotechnology are discussed briefly.

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Section: Delivery Of Chemotherapeutic Drugs By Carbon Nanotubessupporting

confidence: 66%

What are carbon nanotubes’ roles in anti-tumor therapies?

Meng

Hua

2010

Sci. China Chem.

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“…100,101 Some other hydrophobic molecules, such as dexamethasone and doxorubicin, were also deposited on SWNH aggregates, and the resulting conjugates showed antitumor capacity in vitro and in vivo. 89,99,103 SWNH aggregates also were able to carry macromolecules (polyamidoamine dendrimers) useful in gene therapy and release genetic material capable of diminishing the level of a protein directly involved in prostate cancer development. 104 One exciting finding is that SWNH aggregates are able to function as a combined photodynamic and photohyperthermic agent when zinc phthalocyanine (ZnPc) is incorporated in their structure.…”

Section: Figurementioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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Nanocarbon materials have received considerable attention due to their unique structure and properties, which make them promising candidate materials for use in biomedical applications. In this review, we discuss the therapeutic applications of spherical nanocarbon materials, including fullerene nanoparticles, carbon nanohorn aggregates, nanodiamonds and porous carbon nanospheres, and their toxicology in biological systems. We put special emphasis on the antitumor effects of these multifunctional nanoparticles, which operate via novel mechanisms in a highly efficient manner. The low toxicities of these spherical nanocarbon materials as well as the possible effects of shape on toxicity are discussed.

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“…Carbon nanotubular materials, including carbon nanotubes and carbon nanohorns (CNHs), have attracted considerable interest and are promising materials for drug delivery Ajima et al, 2005;Murakami et al, 2008), imaging (Miyawaki et al, 2006;Liu et al, 2009) and photodynamic therapy (Zhang et al, 2008;Moon et al, 2009). However, once they are engulfed by cells, the effects of carbon nanotubules on the function of sub-cellular organelles and biomolecules are not fully understood.…”

Section: Introductionmentioning

confidence: 99%