Water-enabled α-C(sp³)–H amination via [1,6]-hydride transfer: green access to diazepino[6,5,4-cd]indoles

Abstract

Water-enabled α-C(sp3)–H amination of 4-dialkylamino-indole-3-carbaldehydes with primary amines was developed for green synthesis of diazepino[6,5,4-cd]indoles via cascade aldimine condensation/[1,6]-hydride transfer/cyclization.