2022
DOI: 10.1101/2022.09.23.483116
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Water exchange rates measure active transport and homeostasis in neural tissue

Abstract: For its size, the brain is the most metabolically active organ in the body. Most of its energy demand is used to maintain stable homeostatic physiological conditions. Altered homeostasis and active states are hallmarks of many diseases and disorders. Yet there is currently no reliable method to assess homeostasis and absolute basal activity or activity-dependent changes noninvasively. We propose a novel, high temporal resolution low-field, high-gradient diffusion exchange NMR method capable of directly measuri… Show more

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