Water extracts of Polygonum Multiflorum Thunb. and its active component emodin relieves osteoarthritis by regulating cholesterol metabolism and suppressing chondrocyte inflammation

Li, Lanqing; Xu, Hui; Qu, Linghang; Pan, Yijing; Tan, Chunmei; Liu, Xianqiong; Xu, Ke

doi:10.1097/hm9.0000000000000061

Cited by 34 publications

(14 citation statements)

References 36 publications

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“…The advancement of healthcare relies heavily on the emergence of new scientific disciplines, as they foster innovation, provide profound insights into diseases, and introduce fresh solutions to enhance patient outcomes (Chen et al, 2020; Li et al, 2023; Wang et al, 2021; Xia et al, 2023). O. basilicum extract has a rich history spanning thousands of years and has been utilized in various fields such as food preservation, pharmaceuticals, alternative medicine, and natural therapies.…”

Section: Resultsmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

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This paper reports on the findings from a study that aimed to identify and characterize the constituents of Ocimum basilicum extract using gas chromatography–mass spectrometry (GC–MS) analysis, as well as assess the physicochemical properties and stability of nanoemulsions formulated with O. basilicum extract. The GC–MS analysis revealed that the O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for use in the biomedical field, with a small and uniform particle size distribution, a negative zeta potential, and high encapsulation efficiency for the O. basilicum extract. The nanoemulsions exhibited spherical morphology and remained physically stable for up to 6 months. In vitro release studies indicated sustained release of the extract from the nanoemulsion formulation compared to the free extract solution. Furthermore, the developed nanoformulation exhibited enhanced anticancer properties against K562 cells while demonstrating low toxicity in normal cells (HEK293). The O. basilicum extract demonstrated antimicrobial activity against Pseudomonas aeruginosa, Candida albicans, and Staphylococcus epidermidis, with a potential synergistic effect observed when combined with the nanoemulsion. These findings contribute to the understanding of the constituents and potential applications of O. basilicum extract and its nanoemulsion formulation in various fields, including healthcare and pharmaceutical industries. Further optimization and research are necessary to maximize the efficacy and antimicrobial activity of the extract and its nanoformulation.Research Highlights This study characterized the constituents of O. basilicum extract and assessed the physicochemical properties and stability of its nanoemulsion formulation. The O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for biomedical applications, with sustained release of the extract, low toxicity, and enhanced anticancer and antimicrobial properties. The findings contribute to the understanding of the potential applications of O. basilicum extract and its nanoemulsion formulation in healthcare and pharmaceutical industries, highlighting the need for further optimization and research.

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Section: Resultsmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

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“…As a result, the activation of the Nrf2 pathway is intimately connected to the growth of resistant melanomas (Khamari et al, 2018). Ferroptosis is a form of programmed cell death that is accompanied by lipid peroxidation and iron buildup, and it is essential for the regulation of tumor growth (Li et al, 2023). Melanomas that have a high Nrf2/HO‐1 activity level are not susceptible to the ferroptosis cell death pathway.…”

Section: Dual Role Of Nrf2 In Melanoma Metastasismentioning

confidence: 99%

Nrf2 protein in melanoma progression, as a new means of treatment

Feng,

Xu,

Zhang

2023

Pigment Cell Melanoma Res

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Melanoma is a potentially lethal form of skin cancer resulting from the unlimited proliferation of melanocytes. Melanocytic lineage appears to have a greater rate of reactive oxygen species (ROS) production, possibly as a result of exposure to ultraviolet (UV) light and the production of melanin. It has been established that nuclear factor erythroid 2‐related factor 2 (Nrf2) serves as a master regulator of the cellular response to oxidative stresses. Recent research has shown that the Nrf2 and its critical negative regulator Kelch‐like ECH‐associated protein 1 (Keap1) are misregulated in melanoma, and the Keap1‐Nrf2 pathway has emerged as a promising new target for treating and preventing melanoma. In melanoma, Nrf2 may either limit tumor growth or promote its development. This review covers a wide range of topics, including the dual functions played by the Keap1‐Nrf2 signaling pathway in melanoma and the most recent targeting techniques of the Nrf2.

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“…The anti‐inflammatory properties of IgG4 are attributed to its ability to block the binding of IgG1 to C1q, thereby inhibiting the activity of IgG1. [ 9,10 ]…”

Section: Introductionmentioning

confidence: 99%

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

Liu,

Wang,

et al. 2024

J Biochem & Molecular Tox

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Immunoglobulin (Ig) G4 has a distinctive nature, and its involvement in autoimmune disorders is a subject of ongoing debate and uncertainty. A growing body of evidence indicates that IgG4 may play a pathogenic role in the development of systemic lupus erythematosus (SLE). The IgG4 autoantibodies have the capability to bind autoantigens in a competitive manner with other Ig classes, thereby forming immune complexes (ICs) that are noninflammatory in nature. This is due to the low affinity of IgG4 for both the Fc receptors and the C1 complement molecule, which results in a diminished inflammatory response in individuals with SLE. The present study aims to elucidate the significance of IgG4 in SLE. The present discourse pertains to the nascent and suggested modalities through which IgG4 might participate in the pathogenesis of SLE and the potential ramifications for therapeutic interventions in SLE.

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Water extracts of Polygonum Multiflorum Thunb. and its active component emodin relieves osteoarthritis by regulating cholesterol metabolism and suppressing chondrocyte inflammation

Cited by 34 publications

References 36 publications

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Nrf2 protein in melanoma progression, as a new means of treatment

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

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