Using the water footprint (WF) approach to evaluate the water-use efficiency in agricultural production is crucial for assessing the sustainable use of water resources and mitigating water scarcity and pollution. This study calculated the blue, grey, green and total water footprints of spring maize production in Northeast China in 2019 and 2020 and compared the water footprint values at the provincial and municipal scales. In addition, this study analyzed the spatial variation and drivers of the water footprint. The results show that the average water footprints of spring maize production in Northeast China in 2019 and 2020 were 1.78 m3kg−1 and 2.00 m3kg−1, out of which the grey water footprint contributed the most, accounting for 55.19% and 49.85% of the total water footprint, respectively, while the blue water footprint contributed the least, accounting for only 17.44% and 18.68% of the total water footprint. At the provincial level, the water footprint of spring maize production in Northeast China was spatially clustered, with the lowest total water footprint in Heilongjiang Province and the highest total water footprint in Jilin Province. The spatial distribution difference of the spring maize unit yield was the fundamental factor explaining the difference in the water footprint. The precipitation, surface water resources, average temperature, effective irrigated area and the proportion of effective irrigated area also had impacts on the water footprint. This study provides a scientific basis for optimizing the distribution of spring maize production in Northeast China, formulating appropriate sustainable water resource management plans, improving water-use efficiency and realizing sustainable water resource management in Northeast China.