Water-In-Oil-In-Water Double Emulsions: An Excellent Delivery System for Improving the Oral Bioavailability of Pidotimod in Rats

Qi, Xiaole; Wang, Lishuang; Zhu, Jin

doi:10.1002/jps.22443

Cited by 27 publications

(15 citation statements)

References 36 publications

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“…In two-step procedure, firstly W/O emulsion is prepared with a low HLB value surfactant(s) by high energy mixing or homogenization and then this emulsion is dispersed in an aqueous phase containing high HLB value surfactant but this time with relatively low energy mixing [83][84][85].…”

Section: Hydrophilic-lipophilic Balance (Hlb) Conceptmentioning

confidence: 99%

Synthesis and characterization of multi‐hollow opaque polymer pigments

Asmaoğlu

Gündüz

Mavış

et al. 2016

J of Applied Polymer Sci

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Section: Hydrophilic-lipophilic Balance (Hlb) Conceptmentioning

confidence: 99%

Synthesis and characterization of multi‐hollow opaque polymer pigments

Asmaoğlu

Gündüz

Mavış

et al. 2016

J of Applied Polymer Sci

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“…Especially, the water/oil/water multiple emulsions have received a great deal of attention [12][13][14][15][16]. So far，there have no literature reports related to the nattokinase incorporated emulsions, included self-double-emulsifying drug delivery system (SDEDDS).…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of nattokinase-loaded self-double-emulsifying drug delivery system

Wang

Jiang

Wang

et al. 2015

Asian Journal of Pharmaceutical Sciences

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Self-double-emulsifying drug delivery system was prepared by mixing water/oil emulsions with hydrophilic emulsifiers proportionally, which could self-emulsify into water/oil/water multiple emulsions followed by dilution with aqueous media under gastrointestinal motility or mild agitation at the ambient temperature. Nattokinase was encapsulated, then released in vitro and pharmacodynamics study in vivo. Abstract:In the present study, we prepared nattokinase-loaded self-double-emulsifying drug delivery system (SDEDDS) and investigated its preliminary pharmacodynamics.The type and concentration of oil phase, inner aqueous phase and emulsifier were screened to prepare optimum nattokinase-loaded SDEDDS. Next, the optimum formulations were characterized based on microstructure, volume-weighted mean droplet size, self-emulsifying rate, yield, storage stability, in vitro release and in vivo pharmacodynamics studies. The water/oil/water multiple emulsions exhibited typical multiple structure, with relatively small volume-weighted mean droplet size 6.0 ± 0.7 µm and high self-emulsifying ability (self-emulsifying time <2 min). Encapsulation of nattokinase was up to 86.8 ± 8.2%. The cumulative release of nattokinase within 8 h was about 30%, exhibiting a sustained release effect. The pharmacodynamics study indicated that nattokinase-loaded SDEDDS could significantly prolong the whole blood clotting time in mouse and effectively improve the carrageenan-induced tail thrombosis compared with nattokinase solution. Moreover, we showed that SDEDDS could successfully self-emulsify into water /oil/water multiple emulsions upon dilution in dispersion medium with gentle stirring and effectively protect nattokinase activity in gastric environment. Our findings suggested that SDEDDS could be a promising strategy for peptide and protein drugs by oral administration.

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“…Interestingly, these effects are more evident in the setting of immune defects such as senescence, downs syndrome, and cancer. Researches have also demonstrated that pidotimod itself does not have antibacterial activity, but when combined with antibacterial agents, pidotimod can be effective in improving clinical effects, promoting recovery, and shortening therapy time 6,7,8 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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ABSTRACT:The aim of this article was to develop pidotimod dispersible tablet and optimize the ingredients for the tablets. The effect of ingredients (diluents, disintegrants and lubricants) on the characteristics of the tablets was evaluated. The pidotimod dispersible tablets were prepared by wet granulation. The effect of diluents on the tablets was investigated by Carr's index, dissolution, hardness, friability and taste. The effect of disintegrants on the tablets was determined by dissolution and cost. And the effect of lubricants on the tablets was studied by weight, hardness and dissolution behavior. The results showed that the optimum proportion was 400mg pidotimod, 120mg MCC, 80mg mannitol, 120mg CMS-Na, 60mg lactose, 20mg aspartame, 10mg magnesium stearate and 6%PVP 50% ethanol solution. Pidotimod dispersible tablets with optimum proportion showed acceptable taste, hardness, friability, dissolution behavior. The preparation process was simple and the tablets could be prepared by ordinary tablet production equipment. So it is suitable for mass industrialized production. The final tableting formulation and the simplified process both had tremendous potentials in commercial large-scale production.

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Water-In-Oil-In-Water Double Emulsions: An Excellent Delivery System for Improving the Oral Bioavailability of Pidotimod in Rats

Cited by 27 publications

References 36 publications

Synthesis and characterization of multi‐hollow opaque polymer pigments

Synthesis and characterization of multi‐hollow opaque polymer pigments

Preparation and evaluation of nattokinase-loaded self-double-emulsifying drug delivery system

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