'Water-Induced Thermotherapy' for Benign Prostatic Hyperplasia; Results of a Prospective Multi-Center Study

Muschter, R.; Schorsch, I.; Matalon, Gabriel; Yachia, Daniel; Jalkowski, Elias; Timoney, A. G.; Danielli, Lavi; Rüssel, C.; Roder, Thomas; Nordling, Jørgen

doi:10.1097/00005392-199904020-00559

Cited by 4 publications

(7 citation statements)

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“…[5][6][7] The more recent work investigated patients' treatment tolerance, 8,9 long-term clinical results, 8,9,12,14,[16][17][18][19] effects on sexual function, 9,15 and adverse events. 8,9 Research studies Using a 50F balloon at 60°C, Larson and associates 7 treated eight patients with WIT 15 to 30 days prior to a scheduled open adenomectomy.…”

Section: Resultsmentioning

confidence: 99%

“…9 Apart from one study, in which one group of patients was treated for 60 minutes, 7 formed with a treatment balloon inflated to 50F and a temperature setting of 60°C, which is referred to as "standard parameters." 9,[13][14][15][16][17][18][19] The term "enhanced parameters" refers inflation of the treatment balloon to 60F and a treatment temperature of 62°C.…”

Section: Methodsmentioning

confidence: 99%

“…8,9 The WIT Prostatic Catheter is available in nine balloon lengths ranging from 2.0 to 6.0 cm in 0.5-cm increments. In all clinical studies, 2,5,6,[8][9][10][11][12][13][14][15][16][17][18][19][20] cording to the measured length of the prostatic urethra (between the bladder neck and verumontanum). Accurate pretreatment measurement of the prostatic urethral length is essential for selecting the appropriate treatment balloon.…”

Section: Equipmentmentioning

confidence: 99%

“…8,9,[14][15][16][17]19 A total of 125 patients were enrolled at eight study centers and evaluated both short term (3, 6, and 12 months) 9,17 and long term (24 and 36 months). 8,14,16,19 The WIT procedure was well-tolerated using only topical anesthesia.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Interest in sex, sexual activity, and other measures were not affected or were slightly improved by WIT. 8,9,[14][15][16][17]19 a Post-WIT evaluation based on 11 patients (73.3%). Four patients remained in urinary retention.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Conductive Heat: Hot Water-Induced Thermotherapy for Ablation of Prostatic Tissue

Muschter

2003

Journal of Endourology

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Water-Induced Thermotherapy (WIT trade mark ) was developed to treat lower urinary tract symptoms (LUTS) and to reduce bladder outlet obstruction (BOO) secondary to benign prostatic hyperplasia (BPH). The principle is to produce heat-induced coagulative necrosis and secondary ablation of the obstructing hyperplastic tissue. The source of thermal energy is heated water circulated in a proprietary closed-loop system, which includes a specially designed catheter. To date, few papers on WIT have been published in peer-reviewed journals. The initial studies focused on feasibility and safety, while later ones were designed to demonstrate tissue and pathologic effects. In a prospective international study, 125 patients were enrolled at eight study centers and evaluated both short term (3, 6, and 12 months) and long term (24 and 36 months). The duration of indwelling catheterization was as follows: 45.5% of patients were catheter free after 1 week (the minimum required by the protocol), 30.5% after 2 weeks, and the remaining 24.0% after 3 to 5 weeks. No patients were asked to do intermittent catheterization. Adverse events were those commonly seen after manipulation of the lower urinary tract. International Prostate Symptom Score, Quality of Life score, peak uroflow rate (Q(max)), and postvoiding residual urine volume had improved significantly at 12, 24, and 36 months. Data reported in a more recent abstract indicate that favorable effects on symptoms and voiding parameters continue to at least 36 months. The WIT procedure was also associated with statistically significant post-treatment prostate shrinkage (median 3.2 cc) at 12 months compared with baseline. The reported failure rate and the rate of subsequent transurethral resection was 5.6% after 12 months, 9.6% after 24 months, and 11.2% after 36 months. According to the literature, WIT is a useful technique to treat BPH-related LUTS and BOO, with a success rate on an intention-to-treat basis of approximately 90% after 12 months and 75% after 24 months.

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