[1] This study presents the first comparison of seasonal groundwater storage (GWS) variations derived from GRACE satellite data with groundwater-level measurements in the High Plains Aquifer, USA (450,000 km 2 ). Correlation between seasonal GRACE terrestrial water storage (TWS) and the sum of GWS estimated from field measurements (2,700 wells) and soil moisture (SM) simulated by a land surface model is high (R = 0.82). Correlation between GRACE-derived and measured GWS is also significant (R = 0.58). Seasonal GRACE-derived TWS and GWS changes were detectable (! uncertainty) in 7 and 5 out of 9 monitored periods respectively whereas maximum changes (between winter/spring and summer/fall) in TWS and GWS were detectable in all 5 monitored periods. These results show the potential for GRACE to monitor GWS changes in semiarid regions where irrigation pumpage causes large seasonal GWS variations. Citation: Strassberg, G., B. R.Scanlon, and M. Rodell (2007), Comparison of seasonal terrestrial water storage variations from GRACE with groundwater-level measurements from the High Plains Aquifer (USA), Geophys. Res. Lett., 34, L14402,