Water-mediated structuring of bone apatite

Wang, Yan; Euw, Stanislas Von; Fernandes, Francisco M.; Cassaignon, Sophie; Selmane, Mohamed; Laurent, Guillaume; Péhau‐Arnaudet, Gérard; Coelho, Carlos; Bonhomme-Coury, Laure; Giraud‐Guille, Marie‐Madeleine; Babonneau, Florence; Azaı̈s, Thierry; Nassif, Nadine

doi:10.1038/nmat3787

Cited by 269 publications

(429 citation statements)

References 52 publications

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“…Here we focus on the behavior of dry collagen fibrils, to be consistent with the full atomistic simulations we used to parameterize the geometry of our coarse‐grained model 32, 37. Besides, it has been shown that water reacts with hydroxyapatite to form a hydrated layer around the crystal 38. Some preliminary data suggest that the interaction between collagen and mineral can vary significantly depending on the amount of water present in this hydrated layer (data not shown).…”

Section: Methodsmentioning

confidence: 81%

Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content

Dépalle

Qin

Shefelbine

et al. 2015

Journal of Bone and Mineral Research

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Mineralized collagen fibrils are composed of tropocollagen molecules and mineral crystals derived from hydroxyapatite to form a composite material that combines optimal properties of both constituents and exhibits incredible strength and toughness. Their complex hierarchical structure allows collagen fibrils to sustain large deformation without breaking. In this study, we report a mesoscale model of a single mineralized collagen fibril using a bottom‐up approach. By conserving the three‐dimensional structure and the entanglement of the molecules, we were able to construct finite‐size fibril models that allowed us to explore the deformation mechanisms which govern their mechanical behavior under large deformation. We investigated the tensile behavior of a single collagen fibril with various intrafibrillar mineral content and found that a mineralized collagen fibril can present up to five different deformation mechanisms to dissipate energy. These mechanisms include molecular uncoiling, molecular stretching, mineral/collagen sliding, molecular slippage, and crystal dissociation. By multiplying its sources of energy dissipation and deformation mechanisms, a collagen fibril can reach impressive strength and toughness. Adding mineral into the collagen fibril can increase its strength up to 10 times and its toughness up to 35 times. Combining crosslinks with mineral makes the fibril stiffer but more brittle. We also found that a mineralized fibril reaches its maximum toughness to density and strength to density ratios for a mineral density of around 30%. This result, in good agreement with experimental observations, attests that bone tissue is optimized mechanically to remain lightweight but maintain strength and toughness. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).

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Section: Methodsmentioning

confidence: 81%

Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content

Dépalle

Qin

Shefelbine

et al. 2015

Journal of Bone and Mineral Research

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Section: Biomechanical Implications Of Inhibition and Promotion Of MImentioning

confidence: 99%

“…It has been demonstrated that structuring water is trapped as a rigid layer in the disordered outer shell of mineral crystallites and facilitates their co-oriented stacking at an additional hierarchical level 57 . Although amorphous calcium phosphate particles are transient in nature, stable amorphous calcium phosphate hydrophilic coatings on carbonated hydroxyapatite are present even in mature bone 57 . Thus, the structuring role of water is as important within the inorganic phase of skeletal tissues, as it is in the architecture of organic moieties: structural water imparts to bone mineral certain unique properties, such as the nano-size and the poor crystallinity 57 .…”

Section: Biomechanical Implications Of Inhibition and Promotion Of MImentioning

confidence: 99%

“…Although amorphous calcium phosphate particles are transient in nature, stable amorphous calcium phosphate hydrophilic coatings on carbonated hydroxyapatite are present even in mature bone 57 . Thus, the structuring role of water is as important within the inorganic phase of skeletal tissues, as it is in the architecture of organic moieties: structural water imparts to bone mineral certain unique properties, such as the nano-size and the poor crystallinity 57 . From a physico-chemical aspect, the nanoscale size of the crystallites and their low purity, to a limited extent, compensate for the sparingly soluble nature of carbonated hydroxyapatite.…”

Section: Biomechanical Implications Of Inhibition and Promotion Of MImentioning

confidence: 99%

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A materials science vision of extracellular matrix mineralization

et al. 2016

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From an engineering perspective, skeletal tissues are remarkable structures in that they are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical success of skeletal tissues is largely attributable to the process of biomineralization -a tightly regulated, cell-driven formation of billions of inorganic nanocrystals formed from ions found abundantly in body fluids. In this Review, we discuss nature's strategies to produce and sustain appropriate biomechanical properties in mineralizing (by promotion of mineralization) and nonmineralizing (by inhibition of mineralization) tissues. We review how perturbations of biomineralization are controlled over a continuum which spans from the desirable (or defective in disease) mineralization of the skeleton, to pathological cardiovascular mineralization, and to mineralization of bioengineered constructs. A materials science vision of mineralization is presented with an emphasis on the micro-and nanostructure of mineralized tissues recently revealed by state-of-the-art analytical methods, and on how biomineralization-inspired designs are impacting the field of synthetic materials. Web summaryComplex mechanisms are at play in the biomineralization of skeletal tissues and in patholological calcification in the cardiovascular system. In this Review, the physiochemical and biomechanical properties of mineralized tissues, both physiologic and pathophysiologic, and analytical methods to elucidate their finer structure are discussed.

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“…The remaining explanation is that various extents of trapped water within layers of CaP are also contributing. In the physiological situation, water plays a role in structuring bone apatite via water-soluble ACP entrapping a rigid water layer between adjacent apatite platelets 93 . The drop-off observed in O/Ca for 3m P which is absent in 7m P could potentially be explained as follows.…”

Section: 9: Global Eds Resultsmentioning

confidence: 99%

Understanding Biomineralization of Polycaprolactone Surfaces

Hubbard¹

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Water-mediated structuring of bone apatite

Cited by 269 publications

References 52 publications

Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content

Large Deformation Mechanisms, Plasticity, and Failure of an Individual Collagen Fibril With Different Mineral Content

A materials science vision of extracellular matrix mineralization

Understanding Biomineralization of Polycaprolactone Surfaces

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