Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐<i>b</i>]pyridine‐3‐carboxylate Derivatives

Ponduri, Rajasekhar; Kumar, Praveen; Vadali, Lakshmana Rao; Reddy, M. Nagi

doi:10.1002/slct.201801089

Cited by 8 publications

(2 citation statements)

References 85 publications

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“…Further optical studies proceeded, and the results indicated that this scaffold could be tuned to enhance its photochemical properties, to be used as a photodetector. Ponduri et al explored the reactivity of isoxazolyl enamino esters 57 with 3formylchromones 53 to generate new chromenopyridine-based compounds 58 (Scheme 8B) [71]. Optimization of the reaction conditions showed that water was the best solvent, while the use of PEG-400 (10% mol) catalysis at 100 °C was also optimal.…”

Section: Chromonesmentioning

confidence: 99%

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

Pedroso de Lima,

Costa,

Sousa

et al. 2024

Molecules

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The chromenopyridine scaffold represents an important class of heterocyclic compounds exhibiting a broad spectrum of biological properties. This review describes novel and efficient procedures for the synthesis of this scaffold. Herein, several methods were detailed and grouped according to their starting material (e.g., salicylaldehydes, chromones, chromanones and coumarins) and respective biological activity, when reported. This review highlights the potential of the reported synthetic strategies for preparing chromenopyridine derivatives with promising biological activity, paving the way for further developments in drug discovery.

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Section: Chromonesmentioning

confidence: 99%

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

Pedroso de Lima,

Costa,

Sousa

et al. 2024

Molecules

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“…However, solvent plays a prime part in organic reactions by providing a homogeneous mixture and enhancing molecular contacts. To overcome the concerns and developing efficient catalyst systems, using water as a reaction medium is highly desirable in terms of environmentally benign and atom economy.…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid as an Efficient Organocatalyst for the Synthesis of 2‐Substituted‐2,3‐dihydroquinazolin‐4(1H)‐one and 2‐Substituted Quinazolin‐4(3H)‐one in Water

et al. 2020

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An environmentally benign, robust and straightforward protocol has been developed for the synthesis of a diverse array of 2,3‐dihydroquinazolin‐4(1H)‐ones using 2‐aminobenzamide and various aldehydes or ketones. Water, a green solvent was adopted in this methodology replacing hazardous reaction mediums. Further, ascorbic acid, an organocatalyst has been accepted to meet the role of catalyst, thus bypassing the use of noxious metals or hazardous materials, which is another asset of this protocol. The activity of this novel methodology has been further being broadened using an oxidant oxone to synthesize 2‐substituted quinazolin‐4(3H)‐one from aldehyde.

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Green Synthesis Using PEG‐400 Catalyst, Antimicrobial Activities, Cytotoxicity and In Silico Molecular Docking of New Carbazole Based on α‐Aminophosphonate

Nguyen

Quang

et al. 2020

ChemistrySelect

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New analog α–amino phosphate series with high yield through an effective and environmentally friendly protocol using the PEG‐400 catalyst via Kabachnik‐Fields has been reported. They were performed to screen antimicrobial activities by the dish diffusion method, anticancer against MCF‐7, A‐549, and HeLa human cancer cell lines by MTT assay, and carried out in silico molecular docking by Avogadro, AutoDockTools, Discovery Studio 2019 Client, and Molegro Molecular Viewer packages. The 3c and 3h displayed excellent inhibition against Candida albicans and Saccharomyces cerevisiae fungi, respectively. The molecular docking model indicated the reasonable explanations between the receptor and bioactive compounds in vitro of 3c, 3 h, and 3b. The 3c was shown as an excellent inhibitor against Candida albicans, which was a new result in vitro and in silico molecular docking model. The 3c, 3 f, and 3i pointed out excellent inhibitions against HeLa cell lines and new anticancer results of α–amino phosphate compounds. The docking studies of structures against receptors of three human cancer cell lines were conducted and recommended that the hydrogen bonds only formed from active sites of receptors to oxygen atom of the ethoxy group, nitrogen and hydrogen atoms of N−H group, oxygen atom of the P=O double bond group, and the fluorine atoms of the CF3 group in 3i for calculated docking of the receptors of bacteria, fungi, and cancer cell lines to all ligands.

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Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐b]pyridine‐3‐carboxylate Derivatives

Cited by 8 publications

References 85 publications

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

The Chromenopyridine Scaffold: A Privileged Platform in Drug Design

Ascorbic Acid as an Efficient Organocatalyst for the Synthesis of 2‐Substituted‐2,3‐dihydroquinazolin‐4(1H)‐one and 2‐Substituted Quinazolin‐4(3H)‐one in Water

Green Synthesis Using PEG‐400 Catalyst, Antimicrobial Activities, Cytotoxicity and In Silico Molecular Docking of New Carbazole Based on α‐Aminophosphonate

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