Background: Globally, irrigation water deficit (IWD) due to saline intrusion and decreased rainfed continues to affect coastal cultivation regions (CCRs). Coastal lowland regions have increasingly frequent saline intrusion, resulting in the IWD as a part of climate variability. Cu Lao Dung Isle, a terrain-low coastal plain in Vietanm is facing revenue loss due to adverse cultivation conditions in recent years. Methods: The objective of this study was, therefore, to assess the effectiveness of the mixture of brackish and freshwater (MBF) for irrigating the spring crop sugarcane in the 2019/20 season grown in a household farming in Cu Lao Dung Isle. An experiment was exploded with the MBF varying from 1.5 to 5.0 dS m-1 corresponding to 100 and 120% of the crop evapotranspiration (ETc). Determination of daily ETc was conducted simulating the FAO-Penman Monteith model based on the weather data obtained using an automatic weather station, locating in the study area. Result: Based on the findings, the MBF at 3.0 dS m-1 levels corresponding to 120% of ETc was stated to be suitable for normal growth of sugarcane Khonkaen III variety. The results showed that the MBF of increasing levels varying from 3.5 to 5.0 dS m-1 significant influenced the growth process and yield of sugarcane. In general, the utilization of brackish water for irrigating in the CCRs is a suitable solution for economic efficiency.