Water‐Promoted Michael Addition Reaction of Sulfonyl Hydrazides and α, β‐Unsaturated Propionic Acids to 3‐Sulfone Propionic Acids

Abstract

A water-promoted synthesis methodology for constructing 3sulfone propionic acids from sulfonyl hydrazides and α, βunsaturated propionic acids with excellent yields were reported. The green synthesis methodology was promoted by water without any catalyst, ligand and organic solvent. The D 2 O control experiment sufficiently proved that the 2-hydrogen atom of 3-sulfone propionic acid come from water. Moreover, the 3-sulfone propionic acid derivates could be directly purified by crystallization without column chromatography.