The river water is one of the water resources that important in managing environmental sustainability, increasing economic growth, and realizing the social welfare of communities. This study aims to assess and analyze water quality of the Cimanuk river. The analyze of water quality in the Cimanuk river based on the Regulation of Governor of West Java (GWJ) Class 1, United Kingdom Technical Advisory Group (UKTAG), United States Environmental Protection Agency (USEPA), Ministry of Environmental Government Japan (MOEG), and Departement of Environmental Malaysia (DOE). Nemerow's pollution index (NPI) method used to assess the water in the Cimanuk river from the years 2013 to 2018. River water sampling stations of the Cimanuk river are Boyongbong, Sukaregang, Tomo, and Jatibarang. Base on seven physicochemical parameters, this research found that the Cimanuk river is not meet the water quality standards with the value of TSS (81.57132.69 mg/L), BOD (8.416.53 mg/L), COD (33.9226.51 mg/L), DO (5.541.67 mg/L), and Ammonia (0.210.31 mg/L). The degradation of river water quality in the Cimanuk river indicated by increasing NPI value. NPI value of the Cimanuk river ranging from 1.04 to 7.51. The water quality status of the Cimanuk river has been changing from slightly to moderately polluted. Nowadays, water from the Cimanuk river not suitable to be used as a drinking water source. However, it is still feasible to irrigate agricultural land and plantations.