Water scarcity and quality deterioration, driven by rapid population growth, urbanization, and intensive industrial and agricultural activities, emphasize the urgency for effective water management. This study aims to develop a model to comprehensively monitor various water quality parameters (WQP) and evaluate the feasibility of implementing this model in real-world scenarios, addressing the limitations of conventional in-situ sampling. Thus, a comprehensive model for monitoring WQP was developed using a 38-year dataset of Landsat imagery and in-situ data from the Water Information System of Europe (WISE), employing Back-Propagated Artificial Neural Networks (ANN). Correlation analyses revealed strong associations between remote sensing data and various WQPs, including Total Suspended Solids (TSS), chlorophyll-a (chl-a), Dissolved Oxygen (DO), Total Nitrogen (TN), and Total Phosphorus (TP). Optimal band combinations for each parameter were identified, enhancing the accuracy of the WQP estimation. The ANN-based model exhibited very high accuracy, particularly for chl-a and TSS (R2 > 0.90, NRMSE < 0.79%), surpassing previous studies. The independent validation showcased accurate classification for TSS and TN, while DO estimation faced challenges during high variation periods, highlighting the complexity of DO dynamics. The usability of the developed model was successfully tested in a real-case scenario, proving to be an operational tool for water management. Future research avenues include exploring additional data sources for improved model accuracy, potentially enhancing predictions and expanding the model’s utility in diverse environmental contexts.