Water Sensitive Coatings Deposited by Aerosol Assisted Atmospheric Plasma Process: Tailoring the Hydrolysis Rate by the Precursor Chemistry

Abstract

International audienceBiocompatible plasma polymers are expected to be used in various applications in medicine such as drug delivery with a controlled release. In this context we investigated the possibility to monitor the kinetic of hydrolytic degradation of plasma polymers by tailoring the chemistry of the precursor. A homemade precursor way synthesized by grafting acrylate function on both side of a polycaprolactone diol (PCL diol) to produce a PCL diacrylate characterized by IR, NMR, and MS to confirm its chemical structure. Acrylates constitute a promising class of precursors to improve the retention of the integrity of the precursor by working in soft plasma conditions. The plasma polymerization of the so-synthesized precursor have been highlighted by means of a multi technique analytical strategy and ensured the retention of hydrolyzable ester function of the precursor. Finally the thickness consumption during immersion in PBS were performed and found to be slower as compared to the degradation kinetic of a plasma polymerized methacrylic anhydride

Atmospheric Pressure Plasma Polymer of Ethyl Lactate: In Vitro Degradation and Cell Viability Studies

“…For this purpose, a biodegradable assembly is synthesized by plasma at atmospheric pressure using a dielectric barrier discharge (DBD). Similar studies have been made using acrylic monomers . To aim at low toxicity products, ethyl lactate is used as precursor in this study due to its use as pharmaceutical excipient and its low vapor pressure.…”

White paper on the future of plasma science for optics and glass

“…In terms of plasma technologies, the most challenging step, in addition to the deposition of bioglasses described above, is the reliable deposition of polymeric constituents of the nanocomposites, mainly with respect to the possibility of tailoring their chemical composition, their degree of cross‐linking and their dissolution kinetics. Although these issues are not yet fully resolved, and are still the subject of intensive ongoing research, several strategies that enable the control of the desired characteristics of plasma‐deposited polymers have been proposed in the last decade, such as APPLD, aerosol‐assisted deposition at atmospheric pressure, and PAVPD . The next key step is thus a combination of these methods with the plasma‐based deposition of bioglass.…”

Reinforcement of a dodecylacrylate plasma polymer by admixture of a diacrylate or a dimethacrylate cross‐linker

“…They are distinguished from polymer materials because of their random and cross‐linked macromolecular structure coming from extensive fragmentation and recombination occurring in the plasma . This characteristic is detrimental to the fine control of surface chemistry, and therefore plasma processes exhibiting good retention of precursor chemical structure have been investigated . Such discharges can be characterized by a significant decrease of injected power through pulsing of discharge, which can lead to very low mean power levels when ultra‐short pulses are employed .…”

“…Another possibility to decrease the fragmentation of precursor molecule is to employ a post‐discharge configuration, or to significantly decrease the discharge energy by igniting discharges in helium . These configurations can be combined to the injection of the precursor as an aerosol . On the one hand, the energy per molecule is generally much lower because precursor flow is much higher for an aerosol (compared to a bubbler) .…”

“…Such a discharge can be operated at atmospheric pressure, opening the way to in‐line treatment at industrial scale since no vacuum chambers are needed . Moreover, recent works show the possibility of DBD processes to investigate plasma polymer deposition with a high degree of retention of precursor chemical structure …”