Water-soluble acrylamide copolymers. VII. Preparation and characterization of poly(methacrylamide-co-acrylamide)

Klimchuk, Keith A.; Hocking, Martin B.; Lowen, Stephen V.

doi:10.1002/1099-0518(20000901)38:17<3146::aid-pola140>3.0.co;2-f

Cited by 13 publications

(14 citation statements)

References 13 publications

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“…However, the reactivity ratios for the copolymerization of acrylamide and methacrylamide have been reported. 31 The calculated polymer composition of our system based on these values indicates a polymer composition very close to the starting monomer composition.…”

Section: Polymer Synthesismentioning

confidence: 99%

Molecular Imprinting for the Recognition of N-Terminal Histidine Peptides in Aqueous Solution

Hart¹,

Shea²

2002

Macromolecules

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A new procedure for creating macromolecular receptors for peptides using molecular imprinting has been developed. The polymeric receptor exhibits selective uptake of specific N-terminal histidine containing sequences of simple dipeptides. The polymerization and binding are carried out in water. The approach utilizes a strong Ni(II)-His binding to attract the N-terminus histidine of the dipeptide to the polymer surface and secondary interactions between peptide and polymer to discriminate between the peptide sequence. These developments are enabled by utilizing an aqueous based monomer formulation that includes N,N′-ethylenebis(acrylamide) as a water-soluble cross-linking monomer and a polymerizable NTA ligand, which can be used to incorporate nickel and other metals into these polyacrylamides. The Ni-NTA complex provides a strong histidine binding site that draws the dipeptide to the polymer surface. Mild polymerization conditions that utilize low concentrations of water-soluble initiator and low-temperature result in quantitative polymer yields. Variation of monomer composition reveals an optimum cross-linking for achieving maximum selectivity for these polymers.

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Section: Polymer Synthesismentioning

confidence: 99%

Molecular Imprinting for the Recognition of N-Terminal Histidine Peptides in Aqueous Solution

Hart¹,

Shea²

2002

Macromolecules

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“…Because the number‐average degree of polymerization, X n , was expected to vary through each set of copolymers, the trends in M w , 〈 r g 〉, and A 2 values from MALLS and in [η], from viscometry, could be affected by both X n and copolymer composition. An estimate of X n was obtained by substituting M w for M n in an equation given in a preceding article in this series 16. The values of X n for the copolymers NTBAM‐ co ‐AM‐1b (cloudy layer), ‐1b (clear layer), and ‐2 (dialyzed fraction) (Table XI) estimated in this way were significantly different within the copolymer series, with even more significant differences between the copolymer types.…”

Section: Discussionmentioning

confidence: 97%

“…Details of the standardization techniques, procedural checks, and some of the possible sources of error have been discussed in preceding articles in this series 15, 16. Solution behavior was assessed by the average polymer‐chain extension as given by the root‐mean‐squared radius of gyration, 〈 r g 〉, and trends in the values of the second virial coefficient (A 2 ) and weight‐average molecular weight, M w .…”

Section: Discussionmentioning

confidence: 99%

“…The eventual goal was to measure the flocculation performance of these polymers under carefully controlled conditions and then to correlate this to their measured solution properties. The first and second articles in this series describe the synthesis, characterization, and solution‐property measurements of a series of PAM‐ co ‐ N , N ‐dimethylacrylamide and PAM‐ co ‐methacrylamide copolymers as well as their control AM and substituted AM homopolymers 15, 16. The present article continues the project description on the same theme but extends the information obtained to a series of PAM‐ co ‐ N ‐ t ‐butylacrylamide (PAM‐ co ‐NTBAM) polymers and related control homopolymers of AM.…”

Section: Introductionmentioning

confidence: 99%

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Water‐soluble acrylamide copolymers. VIII. Preparation and characterization of polyacrylamide‐co‐N‐t‐butylacrylamide

Hocking

Klimchuk

Lowen

2001

J. Polym. Sci. A Polym. Chem.

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The preparation of a series of copolymers of N‐t‐butylacrylamide (NTBAM) with acrylamide (AM) is reported. The insolubility of NTBAM in water led to the testing of methanol, t‐butanol, and mixtures of these solvents with water to obtain effective copolymerization. Several of these polymerizations produced nonhomogeneous product mixtures. Samples of the components were separated and characterized by photoacoustic Fourier transform infrared spectroscopy and 13C NMR spectroscopy. Hydrodynamic volumes of the products were obtained from solution‐viscosity measurements, gel permeation chromatography, and multi‐angle laser light scattering methods. The NTBAM‐co‐AM copolymers had degrees of polymerization and molecular weights in the 4.1–5.9 × 104 monomer units and 3.25–4.5 × 106 g/mol range, respectively. They contained from 15 to 36 mol % NTBAM. © 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 39: 1960–1977, 2001

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“…MeAM, DMA, and N ‐ t ‐butylacrylamide (NTBAM) are examples of the monomers that we copolymerized with AM in our continuing study of the effect of steric bulk and charge on the solution conformation of these materials. An earlier group of articles reported on the effect of the introduction of bulky hydrophobic groups directly on, or close to, the backbone of the polymer chain on the polymer conformation in solution 25–27. This article follows up on the earlier work by reporting on the preparation and characterization of cationic derivatives of selected examples of the nonionic homopolymers and copolymers prepared earlier.…”

Section: Introductionmentioning

confidence: 91%

Water‐soluble acrylamide copolymers. IX. Preparation and characterization of the cationic derivatives of poly(acrylamide‐co‐n,n‐dimethylacrylamide), poly(acrylamide‐co‐methacrylamide), and poly(acrylamide‐co‐n‐t‐butylacrylamide)

Klimchuk

Hocking

Lowen

2001

J. Polym. Sci. A Polym. Chem.

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This article extends the preparative details of a series of nonionic copolymers of acrylamide with N,N‐dimethylacrylamide, methacrylamide, and N‐t‐butylacrylamide to the synthesis of cationic derivatives of these new copolymers. The described procedures gave products with cationicities of 14–26 mol %. We measured the mean squared radii of gyration and intrinsic viscosities of aqueous solutions of these products at several different pHs and NaCl concentrations to compare these values with those determined for the nonionic precursors and related commercial cationic polymers. Because the molecular weights of the examples measured varied widely, it was difficult to establish definite trends. However, the large values obtained for the mean squared radii of gyration and intrinsic viscosities, relative to the nonionic precursors of these polymers, demonstrated that the charged groups had a qualitatively greater effect on polymer extension than the nonpolar bulky groups. © 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 39: 2525–2535, 2001

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Water-soluble acrylamide copolymers. VII. Preparation and characterization of poly(methacrylamide-co-acrylamide)

Cited by 13 publications

References 13 publications

Molecular Imprinting for the Recognition of N-Terminal Histidine Peptides in Aqueous Solution

Molecular Imprinting for the Recognition of N-Terminal Histidine Peptides in Aqueous Solution

Water‐soluble acrylamide copolymers. VIII. Preparation and characterization of polyacrylamide‐co‐N‐t‐butylacrylamide

Water‐soluble acrylamide copolymers. IX. Preparation and characterization of the cationic derivatives of poly(acrylamide‐co‐n,n‐dimethylacrylamide), poly(acrylamide‐co‐methacrylamide), and poly(acrylamide‐co‐n‐t‐butylacrylamide)

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