Water-soluble Complex of Curcumin with Cyclodextrins: Enhanced Physical Properties For Ocular Drug Delivery

Maria, Doaa Nabih; Mishra, Sanjay R.; Wang, Lijia; Abd-ElGawad, Abd ElGawad Helmy; Soliman, Osama A.; El-Dahan, Marwa Salah; Jablonski, Monica M.

doi:10.2174/1567201813666160808111209

Cited by 34 publications

(21 citation statements)

References 38 publications

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“…Reducing tear osmolality and increasing tear production are well recognized by clinical trials in patients with dry eye disease [Wojtowicz et al, 2011;Georgakopoulos et al, 2016;Deinema et al, 2017], but there is no evidence of its significant effect on meibum lipid composition [Wojtowicz et al, 2011]. Maria et al [2016] have reported a formulated eye drop for curcumin with more aqueous solubility properties named F11. The mechanism of action reported to be decreasing cytokines and inhibiting oxidative stress [Li et al, 2014].…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

“…A topical form of omega-3 fatty acid has been used in combination with hyaluronic acid with a good outcome in the treatment of dry eye in the mouse model. This formulation is sustained-release ones [Maria et al, 2016] and seems interesting in the management of different inflammatory ocular surface diseases in SM-exposed patients, but it needs further studies on animals and clinical trials to approve the formulation. Essential fatty acids should be considered for routine use in SM-exposed victims.…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

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Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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“…Maria designed a water-soluble complex of curcumin with cyclodextrins to make eyedrop delivery possible [67]. In addition, nanoparticles, which have been extensively studied in recent years, are being used as novel drug delivery systems because of their characteristics including biodegradability, non-toxicity, and hydrophilicity.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice

Wang

Yin

Gao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease. Methods: Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice. Results: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retina-derived 661W cells. Conclusions: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP.

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“…This natural hydrophobic polyphenol is proposed as an alternative treatment for dry eye disease [31]. Maria et al [32] have developed a formulated eye drop for curcumin with more aqueous solubility properties. This sustained-release drop may be appropriate for the management of different inflammatory ocular surface disorders encountered in sulfur mustard-exposed patients [32].…”

Section: Medical Managementsmentioning

confidence: 99%

“…Maria et al [32] have developed a formulated eye drop for curcumin with more aqueous solubility properties. This sustained-release drop may be appropriate for the management of different inflammatory ocular surface disorders encountered in sulfur mustard-exposed patients [32]. However, further animal studies and clinical trials are required to approve the efficacy of this formulation.…”

Section: Medical Managementsmentioning

confidence: 99%

Corneal Blindness Caused by Mustard Gas

Feizi¹

2018

Causes and Coping With Visual Impairment and Blindness

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Mustard gas is a lipophilic, highly cytotoxic agent that rapidly penetrates tissue, and the eye is one of the organs mostly affected. Mustard gas-related ocular injuries can be divided into immediate, chronic, and delayed-onset phases. Late complications, developing after 1-40 years, can cause progressive and permanent reduction in visual acuity and even blindness. A wide range of late ocular involvements have been reported, which include chronic blepharitis, limbal ischemia and stem cell deficiency, and corneal scarring and neovascularization. The majority of corneal involvements are limited to the anterior stroma, leaving the posterior stroma and endothelium relatively intact. Therefore, lamellar keratoplasty is appropriate for the management of corneal involvements in the majority of victims. This procedure can be performed alone or in combination with limbal stem cell transplantation.Mustard gas-related ocular injuries can be divided into immediate, chronic, and delayedonset phases [12]. Acute manifestations of varying degrees, including eyelid erythema and edema, chemosis, subconjunctival hemorrhage, epithelial edema, punctate erosions, and corneal epithelial defects, develop in 75-90% of exposed individuals and can follow three different courses: complete resolution, persistent smoldering inflammation (chronic form), or reappearance of lesions after a latent period of quiescence (delayed form) [13,14].Late complications, developing after 1-40 years, can cause progressive and permanent reduction in visual acuity and even blindness, and they occur in approximately 0.5% of those initially

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Water-soluble Complex of Curcumin with Cyclodextrins: Enhanced Physical Properties For Ocular Drug Delivery

Abstract: Based on these results, F11 was formulated as eye drops, which provide a promising once daily novel topical delivery of this naturally derived phytochemical.

Cited by 34 publications

References 38 publications

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice

Corneal Blindness Caused by Mustard Gas

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