Water-soluble Derivative of Nystatin. Preliminary Clinical Experiences

Chemistry and biology of the polyene macrolide antibiotics.

“…Cocchi and his colleagues (68,69,225) solubilized nystatin by making a monohydrochloride. This derivative was reported to be as active as nystatin against Candida albicans in vitro and was effective in the treatment of infections with C. albicans when it was administered orally or by aerosol in doses of 5 to 39 mg daily.…”