Water‐Soluble Heteronuclear [NaCu^II₆] Metallomacrocyclic Sandwich Complexes: Synthesis, Structure, Properties and In Vitro Biological Studies

Abstract

The water-soluble heteronuclear metallomacrocyclic sandwich clusters [NaCu 6 (hpnbpda) 3 (OH) 3 (OH 2 ) 3 ](NO 3 )·4H 2 O (1), [NaCu 6 (hpnbpda) 3 (OH) 3 (OH 2 ) 3 ](ClO 4 ) (2), and [Na-Cu 6 (hpnbpda) 3 (OH) 3 (OH 2 ) 3 ](PF 6 ) (3) [H 3 hpnbpda = N,NЈbis(2-pyridylmethyl)-2-hydroxy-1,3-propanediamine-N,NЈdiacetic acid] have been synthesized in methanol at room temperature and fully characterized using several analytical techniques including single-crystal X-ray diffraction. The molecular architecture of complex 1 is built from the template assembly of three dinuclear [Cu 2 (hpnbpda)] + fragments through their weak oxophillic interactions with a central sodium(I) cation. A close analysis of the single-crystal X-ray structure reveals that the metallic core of cluster 1 consists of six highly distorted octahedral Cu II ions arranged at the corners of a trigonal prism that encapsulates the sodium(I) ion. Complex 1 displays a rare μ 3 :η 2 :η 1 :η 1 bridging mode of six carboxylate groups of three hpnbpda 3ligands with each[a]

Ferrocene‐substituted bis(ethynyl)anthracene compounds as anticancer agents

“…But in the case of 2 and 3 , hypochromism with a blue shift at absorption maxima is observed at 258 and 254 nm, respectively. The hyperchromic effect with blue shift suggests that 1 – 3 bind to DNA by partial intercalation, external contact or may be due to electrostatic binding . The intrinsic binding constants K b are found to be 1.216 × 10 3 , 3.51 × 10 3 and 5.27 × 10 2 M −1 , respectively, for 1 – 3 .…”

“…The binding constants ( K b ) were determined using the equation where [DNA] is the concentration of DNA and ε a , ε f and ε b correspond to the apparent extinction coefficient, the extinction coefficient of unbound compound and the extinction coefficient of fully bounded compound, respectively. A plot of [DNA]/( ε a − ε f ) versus [DNA] gives the binding constant K b as the ratio of the slope to the intercept …”

Crystal structure of bis{μ2-2,2′-[(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(methylene)]bis(4-oxo-4H-pyran-3-olato)}dicobaltcalcium bis(perchlorate) 1.36-hydrate

“…They find applications in many fields, ranging from molecular recognition to transport and catalysis (Gokel & Barbour, 2017;Weber & Gokel, 2012;Ambrosi et al, 2007aAmbrosi et al, ,b, 2008Ambrosi et al, , 2009aMartell & Hancock, 1996;Voegtle, 1996;Zelewsky, 1996;Lehn, 1988), to name just a few. Moreover, they find applications in the field of bioinorganic chemistry (Fanelli et al, 2016;Marchetti et al, 2015;Patra et al, 2014), for instance as anticancer agents (Bruijnincx & Sadler, 2008) and artificial metalloproteases (Suh & Chei, 2008).…”

Synthesis, structure, spectral characterization and DNA binding affinity of new water soluble trinuclear copper(II) complexes with partial cubane Cu3O4 cores

“…However, the systematic and detailed study of such binding and cleavage of biological macromolecules has been sporadic, probably due to the unavailability of structurally characterized highly water soluble trinuclear copper(II) complexes [25,26]. Very recently, we reported di-, tetraand hexanuclear copper(II), zinc(II) and cobalt(II) complexes built upon dinucleating ligands and their binding interactions with various biological micro-and macromolecules in aqueous medium [11,12,22]. While the study has established a strong interaction between the complexes and the biomolecules, none of the complexes had direct structural resemblance to any known metalloprotein.…”

“…The investigation reported that animals treated with the complexes showed several health benefits such as inhibiting tumor growth and metastasis slow-down, host organism survivability, and induction of morphological differentiation of cancerous cells [21]. There are reports in the literature on multinuclear copper(II) complexes which can efficiently promote the binding and cleavage of biological macromolecules [12,[22][23][24]. However, the systematic and detailed study of such binding and cleavage of biological macromolecules has been sporadic, probably due to the unavailability of structurally characterized highly water soluble trinuclear copper(II) complexes [25,26].…”