Water-soluble nickel-bis(dithiolene) complexes as photothermal agents

Mebrouk, Kenny; Chotard, Florian; Goff-Gaillard, Catherine Le; Arlot‐Bonnemains, Yannick; Fourmigué, Marc; Camerel, Franck

doi:10.1039/c4cc08231a

Cited by 39 publications

(41 citation statements)

References 13 publications

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“…Release of CF from photothermosensitive EggPC/DSPE-PEG 2000 liposomes containing5wt %o fNi8C 12 complex in wateri nt he dark. [19] TheI C 50 of Ni8C 12 could not be determinedd ue to its strongh ydrophobicity.I n the case of Lp-Ni8C 12 ,c ytotoxicity is due only to the liposome and not to the encapsulatedc omplex, as the cytotoxicity is the same whether the complex is present or not (Figure 3). ChemMedChem 2017ChemMedChem , 12,1753ChemMedChem -1758 www.chemmedchem.org two cell lines (HeLa andM DA-MB-231)a fter 24 hi ncubation (see SI for details).…”

Section: Introductionmentioning

confidence: 98%

“…Mebrouk more, metal-bis(dithiolene) complexes are non-luminescent. [19] These complexes are also highly stable under NIR laser irradiation, andn op hotobleaching has been observed. [17,18] In addition, properf unctionalization of the complexes has allowed for very good aqueous solubility.M ore importantly,c ell-based experiments have demonstrated that NIR laser irradiation of cell culturesi ncubated with metal-bis(dithiolene) complexes can induce cell death.…”

Section: Introductionmentioning

confidence: 98%

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Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes

et al. 2017

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This work demonstrates that metal-bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near-infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel-bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR-triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal-bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR-responsive materials for application not only in biotechnology but also in materials science.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes

et al. 2017

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“…6 The photothermal properties of water-soluble nickelbis(dithiolene) were also efficiently used in cellulo experiments to induce cell death under laser irradiation. 7 Several liquid crystalline systems build around metal-bis(dithiolene) core have been described in the literature. 8 But, the photothermal properties of this class of metal complexes have never been used to induce thermal transitions.…”

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confidence: 99%

Laser triggered phase transition in photothermal liquid crystals

Ciancone

Camerel

2017

Chem. Commun.

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“…For this purpose, a first series of metal‐bis(dithiolene) complexes functionalized with polyethylene glycol chains was synthesized (Figure ) . Polyethylene glycol chains have been selected for their good water solubility and their biocompatibility.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Toxicological data on metal‐bis(dithiolene) complexes are very limited and the pharmacokinetic of these complexes still have to be evaluated. The only information available is that the IC50 of a nickel‐bis(dithiolene) complex carrying eight triethylene glycol chains is around 500 µg/mL . The IC50 of nickel‐bis(dithiolene) complex carrying long carbon chains could not have been determined due to their strong hydrophobicity.…”

Section: Nanoparticlesmentioning

confidence: 99%

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

Camerel

Fourmigué

2020

Eur J Inorg Chem

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Square‐planar bis(dithiolene) complexes are characterized with a planar delocalized structure and a strong and tunable near infrared (NIR) absorption; they are highly stable under laser irradiation, and their conversion efficiency (light to heat) reaches up to 40–50 %. Their involvement in soft matter, namely liquid crystals, gels, and nanoparticles, opens many possibilities to control the actual state of a material, particularly under light irradiation. Thus, liquid crystalline phases can easily be modified, (i) with temperature to modulate the extended magnetic interactions of paramagnetic complexes, or (ii) under laser irradiation to unravel these remarkable photothermal properties, toward the development of light‐responsive materials. Dithiolene complexes can be also functionalized to produce very effective gelation agents, while the photothermal effect can be used to destabilize at will their supramolecular organization. Besides photothermal therapy, new therapeutic agents were also developed for photo‐controlled drug delivery and bioimaging, combining chemotherapy and phototherapy. Hydrophobic complexes were accordingly designed for their encapsulation in block copolymer nanoparticles for photothermal therapy and photo‐controlled drug delivery under laser irradiation. This class of complexes can be also used as exogenous contrast agents for photoacoustic bioimaging.

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Water-soluble nickel-bis(dithiolene) complexes as photothermal agents

Abstract: The remarkable photothermal properties of pegylated nickel-bis(dithiolene) complexes in water can induce cell death under laser irradiation in the near infrared (NIR) region.

Cited by 39 publications

References 13 publications

Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes

Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel‐bis(dithiolene)‐Containing Liposomes

Laser triggered phase transition in photothermal liquid crystals

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

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