Water soluble organometallic small molecules as promising antibacterial agents: synthesis, physical–chemical properties and biological evaluation to tackle bacterial infections

Abstract

The Na[3,3’-Fe(8-I-1,2-C2B9H10)2] and Na[2,2’-M(1,2-C2B9H11)] (M= Co3+, Fe3+), small molecules are synthesized and the X-ray structures [(H3O)(H2O)5][2,2’-Co(1,7-C2B9H11)2] and [Cs(MeCN)[8,8’-I2-Fe(1,2 C2B9H10)2], both displaying transoid conformation of [M(C2B9)2]- framework, are reported. Importantly, the...

Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma

“…Summary of several physical-chemical properties of the small anionic ferrabis(dicarbollide) molecules. 64 The TGA/DSC studies of Na interacts with DNA and proteins modifying their secondary structure, while interaction with lipids is weaker, being enough to cross the biological membranes (cell and nucleous). 58 This finding has been possible because Na[o-COSAN] displays a strong and characteristic ν(B-H) frequency in the infrared range 2.600-2.500 cm -1 in which no other frequencies of organic compounds appear.…”

“…The sodium salts of ferrabis(dicarbollide) Na[o-FESAN] and Na[8,8 0 -I 2 -o-FESAN] were synthesized from Cs[o-FESAN] 42 and Cs[8,8 0 -I 2 -o-FESAN] 63 by using a cationic exchanging resin as reported in the literature 64 (see ESI, † Scheme S1). 1,2-Dioleoylsn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were purchased from Avanti Polar Lipids (Alabaster, AL).…”

“…Summary of several physical and chemical properties of the small anionic ferrabis(dicarbollide) molecules64 …”

Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents

“…In contrast to organic molecules, metallacarboranes of the type [M­(C 2 B 9 H 11 ) 2 ] − (M = Co, Fe, Ni) are still largely unexplored compounds with extraordinary properties that can be potentially useful in biology and medicine. − The most extensively studied metallacarborane contains a cobalt­(III) cation. , It is termed 3-cobalt bis­(1,2-dicarbollide) ([3,3′-Co­(1,2-C 2 B 9 H 11 ) 2 ] − ) and abbreviated as [COSAN]. The specific features of this 3D aromatic anion include thermal, chemical, and biological stability , as well as good solubility in both organic and aquatic solvents, depending on counterion . From the point of view of intermolecular interactions, [COSAN] shows nonclassical amphiphilic behavior, − partly as a result of delocalization of the anionic charge throughout its volume (giving an anion with low charge density). , [COSAN] produces a strong dihydrogen bond, which enables interactions with amino acids and proteins. , In a biological environment, it can cross lipid membranes without disrupting their integrity and displays low toxicity in vitro and in vivo . , …”

“…The specific features of this 3D aromatic 15 anion include thermal, chemical, and biological stability 16,17 organic and aquatic solvents, depending on counterion. 18 From the point of view of intermolecular interactions, [COSAN] shows nonclassical amphiphilic behavior, 19−21 partly as a result of delocalization of the anionic charge throughout its volume (giving an anion with low charge density). 22,23 [COSAN] produces a strong dihydrogen bond, which enables interactions with amino acids and proteins.…”