Water-Soluble Porphyrin-Based Nanoparticles Derived from Electrostatic Interaction for Enhanced Photodynamic Therapy

Abstract

Pyrrole and porphyrin-derived nanoparticles have great potential use in bioimaging and therapy because of their unique magnetic, optical, and other photophysical properties, whereas the poor solubility in aqueous solution is one of the drawbacks of current photosensitizers for their photodynamic therapy (PDT) applications. Here, we developed a kind of water-soluble porphyrin-based nanoparticles that are coassembled mainly by the electrostatic interaction of anionic porphyrins and cationic tetraphenylmethane derivative. No aggregation-caused quenching (ACQ) was detected for these nanoparticles. In addition, the simple porphyrin transformation into nanoparticles improved their ability to generate reactive oxygen species singlet oxygen (1O2), which is an important factor causing apoptosis. The coassembled water-soluble porphyrin-based nanoparticles exhibited enhanced antitumor efficiency via PDT both in vitro and in vivo.

AIE-active Ir(iii) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

“…[1][2][3] Nevertheless, most of the current PSs, such as boron dipyrromethene (BODIPY) and porphyrin derivatives, need long irradiation times and large amount of PSs to achieve the high generation of ROS owing to their low singlet-to-triplet intersystem crossing (ISC) ability, which limits their PDT efficacy. [4][5][6] The ISC rate depends upon the spin-orbital coupling (SOC) interaction between the lowest triplet and one or more singlet excited states. Because the SOC constant generally increases with atomic number, large SOC interactions are found in molecules comprising heavy atoms and SOC is therefore quite large for Ir (3909 cm −1 ).…”

Recent Developments of Porphyrin Photosensitizers in Photodynamic Therapy

“…This study results compared to pure complex-2, we find that the biotin-decorated, nitrogen-doped graphene quantum dots with porphyrin complex-2 actually boosts its PDT activity efficiently [117]. antitumor activity compared to free porphyrins [119]. Matsui at el.…”

Fabrication of ballpoint-ink via encapsulating inorganic pigments in microemulsion gels

“…[2][3][4] Nowadays, indigo obtained from inorganic salts has not lost its importance because it offers better stability, especially oxidation resistance, compared with organic pigments. 5 However, research on the solubility of inorganic compounds might play an essential role to unlock the physical and chemical aspects of thermodynamics and kinetics of the molecules microscopically, hence this understanding may be helpful for future advanced research, such as in nanotechnology, [6][7][8] nanophotonics, 9 nanocoatings, 10 solar cell fabrication, 11 membrane therapy, 12 drug delivery to cancer cells, anti-counterfeiting material coatings, 13 optical sensors, 14 etc. In addition, the dissolution of inorganic pigments into microemulsions potentially has a bright future, as it can be applied in the pharmaceutical industry and in the conversion of light into energy, solar cells, sensor technology, and photonics.…”