Water-soluble <scp>d</scp>-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

Bony, Badrul Alam; Baeck, Jong Su; Chang, Yongmin; Bae, Jong Hoa; Chae, Kwon Seok; Lee, Gang Ho

doi:10.1039/c4bm00107a

Cited by 10 publications

(11 citation statements)

References 37 publications

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“…Nanoparticles displayed characteristic IR stretches of C = O at 1615 cm −1 and C-O at 1066 cm −1 , indicating the presence of D-glucuronic acid. The IR stretch of 90 cm −1 obtained from free D-glucuronic acid (1705 cm −1 ) evidenced the chemical bonding of its -COOH group with a nanoparticle, as described by Bony Bradul in relation to lanthanide oxide nanoparticles 28 . According to the A-10 Chemicall protocol for fluidMAG-ARA nanoparticles (methodology section), carbodiimides react with the carboxylate groups from the magnetic beads to afford highly reactive O-acylisourea derivatives, which in turn readily react with amino groups of monoclonal antibodies.…”

Section: Discussionmentioning

confidence: 63%

A biosensor capable of identifying low quantities of breast cancer cells by electrical impedance spectroscopy

Huerta-Núñez

Gutiérrez-Iglesias

Martínez-Cuazitl

et al. 2019

Sci Rep

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Breast cancer (BC) is a malignant disease with a high prevalence worldwide. The main cause of death is not the primary tumor, but instead the spread of tumor cells to distant sites. The aim of the present study was to examine a new method for the detection of cancer cells in aqueous medium using bioimpedance spectroscopy assisted with magnetic nanoparticles (MNP’s) exposure to a constant magnetic field. The spectroscopic patterns were identified for three breast cancer cell lines. Each BC cell line represents a different pathologic stage: the early stage (MCF-7), invasive phase (MDA-MB-231) and metastasis (SK-BR-3). For this purpose, bioimpedance measurements were carried out at a certain frequency range with the aid of nanoprobes, consisting of magnetic nanoparticles (MNPs) coupled to a monoclonal antibody. The antibody was specific for the predominant cell surface protein for each cell line, which was identified by using RT-qPCR and flow cytometry. Accordingly, EpCAM corresponds to MCF-7, MUC-1 to MDA-MB-231, and HER-2 to SK-BR-3. Despite their low concentrations, BC cells could be detected by impedance spectroscopy. Hence, this methodology should permit the monitoring of circulating tumor cells (CTC) and therefore help to prevent recurrences and metastatic processes during BC treatment.

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Section: Discussionmentioning

confidence: 63%

A biosensor capable of identifying low quantities of breast cancer cells by electrical impedance spectroscopy

Huerta-Núñez

Gutiérrez-Iglesias

Martínez-Cuazitl

et al. 2019

Sci Rep

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“…Bony et al synthesized D-glucuronic acid coated Ln/Mn (Ln = Gd and Dy) oxide NPs (d avg = 2.0 nm). The D-glucuronic acid coated Gd-NPs displayed strong positive contrast (T 1 MRI) enhancements in 1.5 T [ 121 ]. Dextran coated Gd-NPs synthesized through a one-pot synthesis approach were found to be highly water-dispersible and non-toxic as determined in a cellular cytotoxicity test.…”

Section: Functionalization Of Gd-npsmentioning

confidence: 99%

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

et al. 2021

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Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

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“…The MR contrast capabilities of nanomaterials can be further improved while two paramagnetic metallic ions are integrated into one nanoplatform [140][141][142][143][144][145][146][147][148][149][150][151][152][153][154][155]. For instance, Zhou and coauthors constructed a 4.95 nm triple-mode imaging platform by doping of Mn 2+ and 68 gallium (III) ( 68 Ga 3+ ) into the matrix of copper sulfide (CuS) NDs using BSA as the synthetic template [143].…”

Section: Dual Paramagnetic Metal Nanodotsmentioning

confidence: 99%

“…In addition, the MnIOMCP at can be rapidly excreted from the body through renal clearance (about 75% ID of MnIOMCP found in urine at 24 h post-injection), which illuminates a new pathway for the development of efficient nanotheranostics with high biosafety. In addition, the r 1 and/or r 2 values of Ln 3+ -based nanomaterials could be increased by mixing paramagnetic transition metal ions into them owing to unpaired 3d-electrons of transition metal ions [151][152][153][154][155]. Gao and coauthors reported a facile strategy to design and synthesis of zwitterionic dopamine sulfonate-coated 4.8 nm gadolinium-embedded iron oxide NDs (GdIO@ZDS), which showed a hydrodynamic diameter of about 5.2 nm in both PBS buffer and BSA solution [155].…”

Section: Dual Paramagnetic Metal Nanodotsmentioning

confidence: 99%

The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Sun

2020

Molecules

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The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.

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Water-soluble d-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

Abstract: Mixed (A) Gd/Mn and (B) Dy/Mn oxide nanoparticles are confirmed to be potential T1 and/or T2 MRI contrast agents, respectively.

Cited by 10 publications

References 37 publications

A biosensor capable of identifying low quantities of breast cancer cells by electrical impedance spectroscopy

A biosensor capable of identifying low quantities of breast cancer cells by electrical impedance spectroscopy

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

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