Water-Soluble Stimuli-Responsive Vesicles from Peptide-Based Diblock Copolymers

Chécot, Frédéric; Lecommandoux, Sébastien; Gnanou, Yves; Klok, Harm‐Anton

doi:10.1002/1521-3773(20020415)41:8<1339::aid-anie1339>3.0.co;2-n

Cited by 392 publications

(410 citation statements)

References 26 publications

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“…[55][56][57] Assemblies with Polypeptide Coronas The past two decades have seen several literature reports of aqueous assembly of block copolymers with peptide corona chains, whereby responsiveness is governed in part by changes in the secondary structure. 11,42,[58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] Much of this research focus has been devoted to pH-responsive block copolymers containing peptides such as poly(L-lysine) (PLys) (pKa 10.3) 73 and poly(L-glutamic acid) (PLGA) (pKa 4.3) 70 which exhibit helix-coil transitions associated with the charged state of the amino or carboxylic acid side chains of PLys and PGlu respectively.…”

Section: Assembly and Responsiveness Of Peptide-based Diblock Copolymersmentioning

confidence: 99%

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Ray¹,

Johnson²,

Savin³

2013

J Polym Sci B Polym Phys

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Polypeptide-based amphiphilic block copolymers are an attractive class of materials given their ability to form welldefined aqueous nanoassemblies that respond to external stimulus through secondary structure transitions. This report will highlight recent literature in the area of polypeptide-based block copolymer self-assembly, with the major focus being on how the responsive nature and structural complexity of the polypeptide blocks can be incorporated into systems with complex topologies such as ABA/BAB/ABC triblock copolymers, AB 2 and A 2 B star copolymers, and miktoarm l-ABC star terpolymers. In particular, the role of interfacial curvature changes and how they result in morphology transitions will be discussed. The 'smart' assembly properties of peptides in complex block copolymer topologies can lead to enhanced responsiveness, morphological complexity, and unique morphological transitions with varying solution conditions. V C 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013, 51, 508-523 KEYWORDS: amphiphiles; biomimetic; block copolymers; selfassembly INTRODUCTION Amphiphilic block copolymers are able to self-assemble into well-defined nanostructures in aqueous solution. [1][2][3][4][5] The equilibrium morphology and aggregation number of diblock copolymer assemblies is primarily determined by the balance of three energetic factors: (1) interfacial tension, (2) corona chain crowding, and (3) core chain stretching. The balance of these three factors dictates an equilibrium curvature for the aggregate. 6-8 Typically, solution morphologies formed by amphiphilic block copolymers follow a trend of increasing interfacial curvature. As the hydrophilic fraction is increased in the copolymer, vesicles, cylindrical micelles, and spherical micelles (in the order of increasing interfacial curvature,) are the most common morphologies (Figure 1). 5,9,10 Physically, this is explained as a balance between entropic freedom of the hydrophilic coronal chains and shielding of the hydrophobic blocks from the aqueous solution; as the hydrophilic fraction increases, the chains are more able to effectively stabilize these assemblies without close-packing, and the free energy of the system is lowered when the coronal chains are provided more entropic freedom/mobility through increased curvature.

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Section: Assembly and Responsiveness Of Peptide-based Diblock Copolymersmentioning

confidence: 99%

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Ray¹,

Johnson²,

Savin³

2013

J Polym Sci B Polym Phys

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“…The critical aggregation concentration (c.a.c), which is a measure of the stability and of the physical properties of the aggregate formed, was determined using pyrene as a fluorescent probe. 10 …”

Section: Ii-3-sample Preparationmentioning

confidence: 99%

“…More importantly, the swelling behavior of nanoparticles composed of peptide-based block copolymers can be regulated by pH changes even in high ionic strength media as demonstrated previously by our group. 10 Furthermore, it can be precisely controlled by appropriate design of the amino acid sequence. The self-assembly in water and in organic solvents of these copolymers will be described especially by means of static and dynamic light scattering, small angle neutron scattering and electron microscopy.…”

Section: Introductionmentioning

confidence: 99%

Structure of Polypeptide-Based Diblock Copolymers in Solution: Stimuli-Responsive Vesicles and Micelles

et al. 2005

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Polypeptide-based diblock copolymers forming either well-defined self-assembled micelles or vesicles after direct dissolution in water or in dichloromethane, have been studied combining light and neutron scattering with electron microscopy experiments. The size of these structures could be reversibly manipulated as a function of environmental changes such as pH and ionic strength in water. Compared to other pH-responsive seldassembled systems based on "classical" polyelectrolytes, these polypeptide-based nanostructures present the ability to give a response in highly salted media as the chain conformational ordering can be controlled. This makes these micelles and vesicles suitable for biological applications: they provide significant advantages in the control of the structure and function of supramolecular self-assemblies.

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“…Monomer-aggregate equilibria with similar characteristics, where the monomer concentration is the critical aggregation concentration, are exemplified in work on liposomes and vesicles by Nardin et al (2000) and Chécot et al (2002).…”

Section: Aggregationmentioning

confidence: 99%

Characterisation of aggregates of cyclodextrin-drug complexes using Taylor Dispersion Analysis

Zaman

Bright

Adams

et al. 2017

International Journal of Pharmaceutics

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There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-betacyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass-and z-average hydrodynamic radii. Whereas DLS measurements primarily resolve the large aggregates of ICT01-2588 in its formulation medium, methodology for TDA is described to determine the size and notably to quantify the proportion of monomers in the presence of large aggregates, and at the same time measure the formulation viscosity. Interestingly TDA and DLS have also distinguished between aggregate profiles formed using HP-beta-CD samples from different suppliers. The approach is expected to be widely applicable to this important class of drug formulations where drug solubility is enhanced by cyclodextrin and other excipients. To: The Editor, International Journal of Pharmaceutics From: Rob Forbes and David GoodallWe have revised the manuscript to reflect the amendments of the reviewers. The original cover letter is below.We are submitting this article, which describes novel work showing benefits of use of Taylor dispersion analysis in conjunction with dynamic light scattering to characterize ICT01-2588, a tumour-targeted vascular disrupting agent, in a potential formulation medium containing 10% hydroxypropyl--cyclodextrin as a solubility enhancing agent. Our approach is expected to be widely applicable to this important class of drug formulations where drug solubility is enhanced by cyclodextrin and other excipients, and is a contribution to advancing an understanding of the nature of self-assembly in such complex systems.The lead reviwer suggested is Thorsteinn Loftsson, who is a member of your Editorial Advisory Board. We cite a number of his papers. Of the other suggested referees. We cite work on Taylor dispersion analysis by the other two proposed referees, Ana Ribeiro and Jesper Ostergaard, and Robert HoylstPlease note that if possible we would like to name two corresponding authors, Robert T. Forbes (lead corresponding author) and David M. Goodall (second corresponding author). If this is not possible, it should be just Robert T. Forbes. The bulk of this work was conducted whilst Professor Forbes was at the University of Bradford, which is listed as his affiliation #1. He is currently at the University of Central Lancashire, which is listed as affiliation #2.Regarding declaration of conflict of interest guidelines, please note the foll...

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Water-Soluble Stimuli-Responsive Vesicles from Peptide-Based Diblock Copolymers

Cited by 392 publications

References 26 publications

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

Structure of Polypeptide-Based Diblock Copolymers in Solution: Stimuli-Responsive Vesicles and Micelles

Characterisation of aggregates of cyclodextrin-drug complexes using Taylor Dispersion Analysis

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