Water-Soluble Tb³⁺ and Eu³⁺ Complexes with Ionophilic (Ionically Tagged) Ligands as Fluorescence Imaging Probes

Abstract

This article describes a straightforward and simple synthesis of ionically tagged water-soluble Eu(3+) and Tb(3+) complexes (with ionophilic ligands) applied for bioimaging of invasive mammal cancer cells (MDA-MB-231). Use of the task-specific ionic liquid 1-methyl-3-carboxymethyl-imidazolium chloride (MAI·Cl) as the ionophilic ligand (ionically tagged) proved to be a simple, elegant, and efficient strategy to obtain highly fluorescent water-soluble Eu(3+) (EuMAI) and Tb(3+) (TbMAI) complexes. TbMAI showed an intense bright green fluorescence emission selectively staining endoplasmic reticulum of MDA-MB-231 cells.

A Red‐Emitting Luminescent Material Capable of Detecting Low Water Content in Organic Solvents

“…In addition, the calculated intensity ratio I 2 / I 1 of the 5 D 0 → 7 F 2 and 5 D 0 → 7 F 1 transitions of 6.13 implies that the coordination environment of the Eu 3+ ion is devoid of an inversion center, and this ratio is about 0.67 for a hydrated Eu 3+ species . We assumed that the coordination between terpyridine moieties and Eu 3+ results in displacement of water molecules from the first coordination sphere of Eu 3+ , which consequently causes the remarkable variation of I 2 / I 1 .…”

Thermosensitive Luminescent Lanthanide Complex with Two Photosensitized Ligands

“…The lanthanide complexes with characteristic narrow emission bands based on 4f-4f transitions have been regarded as attractive luminescent materials for use in lasers, (2,3) organic LEDs (4)(5)(6)(7) and bioimaging (8)(9)(10) applications. Efficient energy transfer from organic ligands to lanthanide ions, i.e., photosensitized energy transfer, is required to produce strong luminescence, because the 4f-4f transitions are Laporte forbidden, and as such have small absorption coefficients (ε < 10 M −1 cm −1 ).…”

Solid, Solution and Gas Phase Interactions of an Imidazolium-Based Task-Specific Ionic Liquid Derived from Natural Kojic Acid

“…30 Nanoparticle stabilizing agents, 49 oxidative desulfurization compounds, 50 organocatalysts for multicomponent reactions, [51][52][53][54] reagents in Pd-catalyzed C-C bond formation, 55 asymmetric synthesis 56 and others [57][58][59] are also examples of the potential of TSILs. We have also explored the chemistry of TSILs applying some derivatives as catalysts for multicomponent reactions, [60][61][62] as ligands for organometallic investigations, 63 as reagents for organic reactions mechanistic evaluations, [64][65][66] as ligands for the formation of water-soluble lanthanide-based fluorescent probes, 67 and others. [68][69][70] Motivated by their importance, and due to limited knowledge of the organizational, supramolecular interactions and physicochemical properties of TSILs, we have recently studied the structural organization and supramolecular interactions of the TSIL 1-methyl-3-carboxymethylimidazolium chloride.…”