Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy

Guo, Mengying; Zhou, Kun; Ding, Rui; Zhao, Xiaodan; Zhang, Yueyan; Zhang, Zixi; He, Gang

doi:10.1039/d2tb00129b

Cited by 6 publications

(1 citation statement)

References 57 publications

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“…The excited unpaired electron is able to react with O 2 to produce ROS (O 2 cand cOH) efficiently via an electron transfer mechanism, reducing dependence on oxygen during treatment. 30,[36][37][38][39][40][41] Nevertheless, despite their inherent advantages, the utilization of organic radical PSs in PDI has yet to be explored. Herein, we present a pioneering molecular design strategy wherein stable organic free radicals are employed as substitutes for conventional free radical intermediates [cPS + ]/[cPS − ] typically generated during the photochemical process.…”

Section: Introductionmentioning

confidence: 99%

Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy

Wang,

Shi,

Wei

et al. 2024

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy

Wang,

Shi,

Wei

et al. 2024

Chem. Sci.

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Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Xin

Kwek

et al. 2023

ChemPlusChem

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The emergence of multi‐drug resistant bacteria strains has been an uphill battle in modern healthcare worldwide, due to the increasing difficulty of killing them. The evolving pathogenicity of bacteria has led to researchers searching for more effective antimicrobial therapeutics to successfully eliminate them without undesirable consequences to the human body. In recent years, antimicrobial photodynamic therapy (APDT), an obsolete technique for cancer treatments, has been reported to eradicate bacteria and biofilm‐related infections. The principle of antimicrobial photodynamic therapy solely relies on the photosensitizers (PSs) generating reactive oxygen species, in the presence of oxygen and light, to destroy pathogens. Thus, it can target a broad spectrum of microorganisms, owing to the indirect interaction between PSs and the bacteria, resulting in the less likelihood for the development of drug resistant bacteria strains. This review will focus on the recent progress of APDT in the last five years and some future perspectives of APDT. The mechanism of APDT against bacteria and biofilms, various PSs used for APDT, and some common multidrug‐resistant bacteria strains will be briefly introduced. The reported in vivo applications of APDT in the several types of bacterial infections that includes periodontitis, wound infections, keratitis, endophthalmitis and tuberculosis in the last five years will be summarized in detail.

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Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics

Xu,

Zhang,

Wang

et al. 2025

Biomaterials

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Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy

Abstract: A series of water-soluble cationic thienoviologen derivatives photosensitizers (nTPy-Rs) for photodynamic therapy (PDT) is reported. The cationic pyridine groups were introduced into thiophene framework to enhance solubility and bacteria binding...

Cited by 6 publications

References 57 publications

Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy

Fine-tuning of stable organic free-radical photosensitizers for photodynamic immunotherapy

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics

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