Water sorption, binding and solubility of polyols

Cohen, Shlomo; Marcus, Yizhak; Migron, Yoelit; Dikstein, S.; Shafran, Avi

doi:10.1039/ft9938903271

Cited by 56 publications

(51 citation statements)

References 11 publications

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“…It emerges from the results obtained with Lotio Cordes, which does not contain glycerol, that shake lotions must not be used indiscriminately in dermatologic therapy. The hydrating effect of glycerol is well established in the literature [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

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Do Shake Lotions, Zinc Oil and Polyethylene Glycol Gels Produce Dehydration or Moisturization?

Gloor

Haus²,

Fluhr³

et al. 2001

Skin Pharmacol Physiol

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We carried out three studies to evaluate the effects of white zinc shake lotion (Zinkschüttelmixtur DAC), zinc oil ( Zinköl NRF 11.20), Lotio Cordes^®, PEG ointment (Polyethylenglykolsalbe DAB) and PEG paste on nonmoisturized and moisturized skin. The aim of the study was a clear indication for these vehicles in the clinical practice. Studies 1 and 2 were performed on 20 healthy volunteers. Study 1 was carried out on nonmoisturized skin, while test areas in study 2 were treated with the study products after 1-hour moisturization with hydrophilic aqueous ointment (hydrophile wasserhaltige Salbe DAB), covered with a semiocclusive film dressing. Study 3, carried out on 10 subjects, differed from study 2 by a longer follow-up period. The water content of the horny layer before and after application of the different vehicles was estimated by the capacitance measurement (Corneometer CM 820) and the conductance measurement (Skikon). The glycerol-containing zinc shake lotion and both PEG gels (with or without zinc oxide) produced hydration under the conditions of study 1 and 2. Zinc oil and moisturizer-free Lotio Cordes had little impact on stratum corneum hydration under the conditions of studies 1–3. Therefore, zinc shake lotion and the two PEG ointments can be used in the treatment of dry atopic skin, but not in overhydrated skin, e.g. in intertriginous regions. Zinc oil and Lotio Cordes can be used in overhydrated skin but not in dry skin, for the missing water-binding capacity in the horny layer. On the other hand an effective dehydrating effect cannot be expected.

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Section: Discussionmentioning

confidence: 99%

“…The effect of polyethylene glycol (PEG) gels on stratum corneum hydration has never been studied. PEG gels are hygroscopic [2]. If they remain on the skin surface and do not penetrate into the stratum corneum, PEG gels may cause dehydration of the skin.…”

mentioning

confidence: 99%

Do Shake Lotions, Zinc Oil and Polyethylene Glycol Gels Produce Dehydration or Moisturization?

Gloor

Haus²,

Fluhr³

et al. 2001

Skin Pharmacol Physiol

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“…The moisture content, watersoluble matter, water uptake degree, water vapor permeability, mechanical resistance like strength and elongation at break, glass transition temperature, morphology, color and opacity were determined and the values found were compared to films with glycerol, seeking a compromise between flexibility and stability. Cohen et al (1993); 2) Bär (1991); 3) Griffin and Lynch (1980).…”

Section: Introductionmentioning

confidence: 99%

Physical evaluation of biodegradable films of calcium alginate plasticized with polyols

Santana

Kieckbusch

2013

Braz. J. Chem. Eng.

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-The influence of different polyols as plasticizers of alginate films on their physical attributes like moisture content, soluble mass in water, water uptake, water vapor permeability, opacity and mechanical properties were determined and the results discussed based on scanning electron microscopy observations and glass transition temperature. The alginate films were obtained by casting, using three different gramatures. Calcium crosslinked and non-reticulated films were considered. The films plasticized with glycerol and xylitol were more hygroscopic than the films with mannitol. The lowest water vapor permeability values were found for films plasticized with mannitol, at all studied thicknesses. The films plasticized with glycerol and xylitol showed very similar functional attributes regarding their application as food wrappings. The Ca 2+ crosslinked mannitol films showed the highest tensile strength at rupture (>140 MPa).

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“…The first is a chiral and the second is a meso form. The presence of four hydroxyl groups attached to different carbon atoms gives rise to a complex system of intermolecular and intramolecular hydrogen bonds, which play an important role in the molecular structure of these compounds and, therefore, in many properties of polyols, namely the sweetness, 1 hygroscopicity 2 and cryopreservation, 3,4 among others. Despite the existence of some published data concerning the solid state, [5][6][7][8][9][10][11][12] we are not aware of any theoretical or experimental data on the structure of erythritol and threitol in the gas state.…”

Section: Introductionmentioning

confidence: 99%

Conformational study of erythritol and threitol in the gas state by density functional theory calculations

Jesus

Tomé

Rosado

et al. 2005

Carbohydrate Research

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Abstract-Density functional theory calculations using the B3LYP functional and the 6-311++G(d,p) basis set were carried out on the isolated molecules of erythritol and L L-threitol. For the meso isomer, a relatively large number of conformers have to be considered to describe the gas state structure. The lowest energy conformer is characterized by the establishment of a strong intramolecular H-bond between the two terminal hydroxyl groups, giving rise to a seven-membered ring and two additional weaker H-bonds between vicinal OH groups. In the case of L L-threitol, two conformers are predominant in the gas state, and both are stabilized by the formation of a cyclic system of four intramolecular hydrogen bonds involving all OH groups. The conformational stability in both diastereomers is discussed in terms of the electronic energy and of the Gibbs energy. The weighted mean enthalpy of both diastereomers in the gas state at 298.15 K was obtained from the thermodynamic data and Boltzmann populations of the low-energy conformers.

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Water sorption, binding and solubility of polyols

Cited by 56 publications

References 11 publications

Do Shake Lotions, Zinc Oil and Polyethylene Glycol Gels Produce Dehydration or Moisturization?

Do Shake Lotions, Zinc Oil and Polyethylene Glycol Gels Produce Dehydration or Moisturization?

Physical evaluation of biodegradable films of calcium alginate plasticized with polyols

Conformational study of erythritol and threitol in the gas state by density functional theory calculations

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