Water source as risk factor for Helicobacter pylori infection in Peruvian children

Opekun, AntoneR.; Smith, Evan; Klein, P.D.; Graham, D.Y.; Gaillour, A.; Group, Gastrointestinal Physiology Working

doi:10.1016/0140-6736(91)93196-g

Cited by 495 publications

(341 citation statements)

References 7 publications

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“…pylori may be transmitted via the fecal-oral or oral-oral infection route in early childhood (Klein et al ,1991;Kusters et al, 2006 ), environmental/lifestyle factors, including sanitary conditions, water sources, living conditions, family size, and socioeconomic status, appeared critical. It seemed that sanitary/environmental conditions remain basic in Mataram, Lombok island, Indonesia.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, H. pylori infection is more prevalent in developing countries, varying with the geographic area, age, socioeconomic status, race, and ethnicity. The precise transmission route is unknown, but most individuals may become infected in childhood (Klein et al, 1991). H. pylori is an important gastrointestinal pathogen associated with chronic gastritis, gastric or duodenal ulcers, and gastric cancer (Asaka et al, 1994;Honda et al, 1998;Peek et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

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Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

Zhao¹,

Wang²,

Tanaka³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

Zhao¹,

Wang²,

Tanaka³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…128,142 Estudo epidemiológico realizado por Klein et al, 63,64 em Lima, verificou que crianças que consomem água fornecida por rede municipal apresentam risco três vezes maior de contrair a infecção pelo H. pylori que aquelas cujas residências são supridas por fonte de água da comunidade. Observou-se também que crianças de família de alto poder aquisitivo que consomem água da rede pública apresentam 12 vezes mais infecção que as de igual poder aquisitivo que utilizam água de outra fonte para o consumo.…”

Section: Transmissão Por Via Oral-oralunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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“…Although other reservoirs, such as water, have been proposed 12 , humans appear to be the primary natural reservoir of H. pylori infection. The route of transmission of H. pylori in man is postulated to be faecal-oral, gastric-oral (in vomitus) or from the consumption of contaminated vegetables 13 .…”

mentioning

confidence: 99%

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Mohammad¹,

Hussein²,

Coward

et al. 2008

Public Health Nutr.

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Objective: The study aim was to assess the prevalence of Helicobacter pylori infection in Egyptian schoolchildren and its effect on growth parameters. Design: A cross-sectional population-based study was conducted among 286 schoolchildren (168 boys and 118 girls), with a mean age of 11.04 6 0.19 years, to determine the prevalence of H. pylori. The presence of the bacterium was assessed using the [ 13 C]urea breath test. Relevant personal and socio-economic data on risk factors for infection were collected. Height and weight were analysed in relation to H. pylori infection. Results: The overall prevalence of H. pylori infection was 72.38%. Attending school in a socially deprived area and residing in an overcrowded home were the major risk factors for infection. Differences between infected and non-infected children were significant with regard to body weight and height (weight: 39.5 6 1.0 vs. 44.6 6 1.8 kg, P 5 0.05; height: 139.9 6 1.3 vs. 144.2 6 2.1 cm; P 5 0.009). The number of children (both boys and girls) falling below the 5th percentile of height-for-age was significantly higher in infected than non-infected children (P 5 001), similarly for Z-scores for height-for-age below -2.0 (P 5 0.003). Conclusion:The results demonstrate not only that the prevalence of H. pylori infection is extremely high among Egyptian schoolchildren, but also that the adverse effects of the infection reach far beyond the stomach. Evidence of the burden of infection on growth failure is presented.

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Water source as risk factor for Helicobacter pylori infection in Peruvian children

Cited by 495 publications

References 7 publications

Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

Association Between HLA-DQ Genotypes and Haplotypes vs Helicobacter pylori Infection in an Indonesian Population

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

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