The experimental Sandhill Wetland is the first permanent reclamation of a composite tailings deposit, and annual water quality monitoring is of specific interest for evaluating and predicting long-term reclamation performance. Here, we present water chemistry monitoring data obtained from Sandhill Wetland (years 2009–2019) and compare results to twelve natural reference wetlands and to environmental quality guidelines for Alberta surface waters. By comparing water quality at Sandhill Wetland and natural sites to established guidelines, we can begin to document the natural background water quality of wetlands in the region and examine if guideline exceedances are seen in natural undisturbed environments, or appear only at active reclamation sites. At Sandhill Wetland the dominant ions in near-surface water were bicarbonate, sulfate, chloride, sodium, calcium, and magnesium. Since the first growing season concentrations for these ions have increased annually, causing concurrent increases in electrical conductivity. In year 2019, water chemistry at Sandhill Wetland was most comparable to regional saline fens, systems that exhibit elevated electrical conductivity and high sodicity. Near-surface water at Sandhill Wetland exceeded water quality guidelines for three substances/properties (dissolved chloride, iron, and total alkalinity) in the most recent year of monitoring. The saline fen natural sites also exceeded water quality guidelines for the same chemical substances/properties, suggesting guideline exceedances are a norm for some natural wetland site types in the region. Of note, in each year of monitoring at Sandhill Wetland, dissolved organic compounds evaluated in sub- and near-surface water were below detection limits.