2014
DOI: 10.1016/j.aquatox.2014.05.024
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Waterborne cadmium and nickel impact oxidative stress responses and retinoid metabolism in yellow perch

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Cited by 31 publications
(27 citation statements)
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References 68 publications
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“…By comparison, in our study, fish exposed to a lower Cd concentration at 20˚C accumulated three-fold less Cd in their kidney than in the Defo et al study, which likely explains the absence of response of G6PDH in our Cd-exposed fish. Fish exposed to Ni in the Defo et al (2014) study accumulated Ni in their kidney to reach concentrations similar to what we observed in our fish exposed at 20˚C. The liver activity of G6PDH was not affected by Ni exposure in either study.…”
Section: Effects Of Metal Accumulationsupporting
confidence: 86%
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“…By comparison, in our study, fish exposed to a lower Cd concentration at 20˚C accumulated three-fold less Cd in their kidney than in the Defo et al study, which likely explains the absence of response of G6PDH in our Cd-exposed fish. Fish exposed to Ni in the Defo et al (2014) study accumulated Ni in their kidney to reach concentrations similar to what we observed in our fish exposed at 20˚C. The liver activity of G6PDH was not affected by Ni exposure in either study.…”
Section: Effects Of Metal Accumulationsupporting
confidence: 86%
“…The liver activity of G6PDH was not affected by Ni exposure in either study. However, although Defo et al (2014) reported a sharp increase in the transcription level of g6pdh in their Ni-exposed fish, which they interpreted as an investment aiming at maintaining G6PDH activity, in the present study at 20˚C the transcription level of the gene was strongly suppressed in control and metalexposed fish, while enzyme activity was maintained. Hence, although the functional response (G6PDH activity) was comparable in both studies, the major difference in the transcription level of the corresponding gene between the two studies cannot be explained within our experimental design, in which the time course of biomarker response was not monitored.…”
Section: Effects Of Metal Accumulationcontrasting
confidence: 74%
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“…Thus, Zn and Cd toxicity is a well-studied topic in the field of aquatic toxicology. However, most studies have merely focused on the effects of the single Zn or Cd exposure on growth, survival, and oxidative stress in fish (Defo et al, 2014;Zheng et al, 2016aZheng et al, , 2016b. The molecular mechanisms that underlie these differences remain to be elucidated.…”
Section: Discussionmentioning
confidence: 98%