The 2010 Deepwater Horizon oil spill in the Gulf of Mexico (GoM) was an environmental disaster, which highlighted the urgent need to predict the transport and dispersion of hydrocarbon. Although the variability of the atmospheric forcing plays a major role in the upper ocean circulation and transport of the pollutants, the air-sea interaction on various time scales is not well understood. This study provides a comprehensive overview of the atmospheric forcing and upper ocean response in the GoM from seasonal to diurnal time scales, using climatologies derived from long-term observations, in situ observations from two field campaigns, and a coupled model. The atmospheric forcing in the GoM is characterized by striking seasonality. In the summer, the time-average large-scale forcing is weak, despite occasional extreme winds associated with hurricanes. In the winter, the atmospheric forcing is much stronger, and dominated by synoptic variability on time scales of 3-7 days associated with winter storms and cold air outbreaks. The diurnal cycle is more pronounced during the summer, when sea breeze circulations affect the coastal regions and nighttime wind maxima occur over the offshore waters. Realtime predictions from a high-resolution atmosphere-wave-ocean coupled model were evaluated for both summer and winter conditions during the Grand