This paper presents an assessment of offshore wave energy potential at the scale of the whole Mediterranean Sea. The offshore wave data were propagated, by means of numerical modeling, toward four Italian coastal areas, namely stretches of coast of Tuscany, Liguria, Sardinia and Sicily. For each area, the wave power and the monthly, seasonal and annual variability at water depths of 50 m and 15 m were analyzed and hotspots were located. The results show strong variability of the wave energy potential from point to point of the same area thus highlighting the need for spatially detailed analysis. The higher values of wave energy potential are located in the hotspots of Sardinia and Sicily, at 11.4 kW/m and 9.1 kW/m, respectively. The Tuscany and the Liguria hotspots are characterized, respectively, by 4.7 kW/m and 2.0 kW/m. In order to point out which state of the art WEC is best suited for the Italian areas, the performances of six different state of the art Wave Energy Converters (WECs) were evaluated. Finally, a comparison of the performances of each WEC in the selected Italian sites and in some European (EU) oceanic sites was conducted. The energy potential in the most energetic EU oceanic site, among those here investigated, is up to 38-times greater than the potentials in the studied Italian areas but the power output, of the best WEC technology, is no more than nine times greater.